Acetate → methyl 4-(tert-butoxycarbonylamino)-1-(5-cyclopropyl-7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxylate

HRID 664828

Reaktionsgleichung

Reaktionsgleichung von HRID 664828
[Br:1][c:2]1[cH:3][n:4]([S:29](=[O:30])(=[O:31])[c:32]2[cH:33][cH:34][c:35]([CH3:36])[cH:37][cH:38]2)[c:5]2[n:6][cH:7][n:8][c:9]([N:11]3[CH2:12][CH2:13][C:14]([C:17](=[O:18])[O:19][CH3:20])([NH:21][C:22](=[O:23])[O:24][C:25]([CH3:26])([CH3:27])[CH3:28])[CH2:15][CH2:16]3)[c:10]12.[CH3:64][c:65]1[cH:66][cH:67][cH:68][cH:69][cH:70]1.[CH3:72][CH2:73][O:74][C:75]([CH3:76])=[O:77].[CH:39]1([P:40]([CH:44]2[CH2:45][CH2:46][CH2:47][CH2:48][CH2:49]2)[CH:52]2[CH2:43][CH2:42][CH2:41][CH2:56][CH2:57]2)[CH2:50][CH2:51][CH2:53][CH2:54][CH2:55]1.[CH:58]1([B:59]([OH:60])[OH:61])[CH2:62][CH2:63]1.[O-:79][C:80]([CH3:81])=[O:82].[O-:83][C:84]([CH3:85])=[O:86].[OH2:71].[Pd+2:78]>>[c:2]1([CH:56]2[CH2:52][CH2:57]2)[cH:3][n:4]([S:29](=[O:30])(=[O:31])[c:32]2[cH:33][cH:34][c:35]([CH3:36])[cH:37][cH:38]2)[c:5]2[n:6][cH:7][n:8][c:9]([N:11]3[CH2:12][CH2:13][C:14]([C:17](=[O:18])[O:19][CH3:20])([NH:21][C:22](=[O:23])[O:24][C:25]([CH3:26])([CH3:27])[CH3:28])[CH2:15][CH2:16]3)[c:10]12

Komponenten

9

Edukt 8

HCID 175Acetate2×HCID 962WaterHCID 1140TolueneHCID 8857Ethyl AcetateHCID 75806TricyclohexylphosphineHCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 2760897Cyclopropylboronic acidHCID 57750316methyl 1-(5-bromo-7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4-(tert-butoxycarbonylamino)piperidine-4-carboxylate

Produkt 1

HCID 57750287methyl 4-(tert-butoxycarbonylamino)-1-(5-cyclopropyl-7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxylate

Quellen und Nachweise

ORD-Eintrag
ord-41027667c4614b49aa68e828d6fd4079
Quelldatensatz
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

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