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Sulfamic Acid → 6,7-Bis(ethoxycarbonyloxy)chromone-3-carboxylic acid

HRID 67091
Notizen
Druckvorschau

Reaktionsgleichung

Reaktionsgleichung von HRID 67091
[CH2:1]([O:3][C:4]([O:6][C:7]1[CH:8]=[C:9]2[C:14](=[CH:15][C:16]=1[O:17][C:18]([O:20][CH2:21][CH3:22])=[O:19])[O:13][CH:12]=[C:11]([CH:23]=[O:24])[C:10]2=[O:25])=[O:5])[CH3:2].S(=O)(=O)([OH:28])N.Cl([O-])=O.[Na+]>ClCCl.O>[CH2:1]([O:3][C:4]([O:6][C:7]1[CH:8]=[C:9]2[C:14](=[CH:15][C:16]=1[O:17][C:18]([O:20][CH2:21][CH3:22])=[O:19])[O:13][CH:12]=[C:11]([C:23]([OH:28])=[O:24])[C:10]2=[O:25])=[O:5])[CH3:2]
KomponentenVersuchsvorschriftAufarbeitungQuellen und NachweiseNotizen zur Reaktion

Komponenten

6

Edukt 3

HCID 5987Sulfamic AcidHCID 128006236,7-Bis(ethoxycarbonyloxy)chromone-3-carboxaldehydeHCID 23668197Sodium Chlorite

Produkt 1

HCID 128006246,7-Bis(ethoxycarbonyloxy)chromone-3-carboxylic acid

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittel2×
HCID 6344
Dichloromethane
Lösungsmittel

Versuchsvorschrift

The compound (1.05 g) obtained in (2) was dissolved in of dichloromethane (31.5 ml) and a solution of 1.05 g of sulfamic acid in water (18.9 ml) was added at 10° C. with stirring. Then, a solution of sodium chlorite (525.6 mg) in water (1.2 ml) was added. The solution was stirred at the same temperature for 1 hour, and allowed to separate. The dichloromethane layer was washed with water (once) and then with a saturated aqueous solution of sodium chloride (twice), and dried over magnesium sulfate. The solvent was distilled off, and ethyl ether was added to the residue to triturate it. The triturated product was collected by filtration, and dried to afford the desired product (950 mg).

Aufarbeitung

  1. stirringThe solution was stirred at the same temperature for 1 hour
  2. customto separate
  3. washThe dichloromethane layer was washed with water (once) and then with a saturated aqueous solution of sodium chloride (twice), and
  4. dry with materialdried over magnesium sulfate
  5. distillationThe solvent was distilled off
  6. additionethyl ether was added to the residue
  7. customto triturate it
  8. filtrationThe triturated product was collected by filtration
  9. customdried

Quellen und Nachweise

ORD-Eintrag
ord-4af7f5458ec34fecb17cc608fbfb5e95
Quelldatensatz
uspto-grants-1982_08
DOI
10.6084/m9.figshare.5104873.v1
Patentnummer
US04344944

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