5-Chloro-7-(cyclopropylamino)pyrazolo[1,5-a]pyrimidine-3-carbonitrile → N-[5-[[3-cyano-7-(cyclopropylamino)pyrazolo[1,5-a]pyrimidin-5-yl]amino]-2-[(3S)-3-(dimethylamino)pyrrolidin-1-yl]phenyl]acetamide

HRID 675

Reaktionsgleichung

Reaktionsgleichung von HRID 675
CC(=O)Nc1cc(N)ccc1N1CC[C@H](N(C)C)C1.N#Cc1cnn2c(NC3CC3)cc(Cl)nc12>CC(=O)N(C)C.CC1(C)c2cccc(P(c3ccccc3)c3ccccc3)c2Oc2c(P(c3ccccc3)c3ccccc3)cccc21.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C([O-])[O-].[Cs+].[Cs+].[Pd].[Pd]>CC(=O)Nc1cc(Nc2cc(NC3CC3)n3ncc(C#N)c3n2)ccc1N1CC[C@H](N(C)C)C1

Komponenten

7

Edukt 2

HCID 898271735-Chloro-7-(cyclopropylamino)pyrazolo[1,5-a]pyrimidine-3-carbonitrileHCID 166477480N-[5-amino-2-[(3S)-3-(dimethylamino)pyrrolidin-1-yl]phenyl]acetamide

Produkt 1

HCID 127045538N-[5-[[3-cyano-7-(cyclopropylamino)pyrazolo[1,5-a]pyrimidin-5-yl]amino]-2-[(3S)-3-(dimethylamino)pyrrolidin-1-yl]phenyl]acetamideAusbeute 36,66 %

Reagenzien, Katalysatoren, Lösungsmittel 4

HCID 10796Cesium carbonateReagenzHCID 6360441,1'-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis(1,1-diphenylphosphine)KatalysatorHCID 9811564Bis(dibenzylideneacetone)palladiumKatalysatorHCID 31374DimethylacetamideLösungsmittel

Reaktionsbedingungen

Temperatur
150 °C

Versuchsvorschrift

in microwave tube was 5-chloro-7-(cyclopropylamino)pyrazolo[1,5-a]pyrimidine-3-carbonitrile (100mg, 0.43 mmol), [Reactants], and (9,9-dimethyl-9H-xanthene-4,5-diyl)bis(diphenylphosphine) (24.76 mg, 0.04 mmol) in DMA (1.0 mL).Pd2(dba)3 (19.60 mg, 0.02 mmol) and cesium carbonate (279 mg, 0.86 mmol) were added. degassed, filled with N2.capped. then microwave 150C for 30 min. filtered, then concentrated. The crude material was purified by ISC(Hex to Hex:EtOAc=1;1 to EtOAc to EtOAc:MeOH=10:1 to EtOAc:MeOH:Et3N=10:1:0.1)) to give no very pure product. collect the product fraction, concentrated to dryness. no pure enough, tried to form solid. it failed sent to ananlytic group for purification. came back. it was OK 1TFA salt. NMR LCMS are OK

Quellen und Nachweise

ORD-Eintrag
ord-6ca842b2903f47c19f42752e7a96ea52
Quelldatensatz
750 AstraZeneca ELN dataset
Originallink
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