Acetic Anhydride → HCID 68991904, Verbindung

HRID 69501

Reaktionsgleichung

Reaktionsgleichung von HRID 69501
[O:1]1[CH2:5][CH2:4][CH2:3][C@@H:2]1[CH2:6][O:7][C:8]1[CH:9]=[C:10]2[C:14](=[CH:15][CH:16]=1)[C:13](=[O:17])[CH2:12][CH2:11]2.[C:18]([O:21]C(=O)C)(=[O:20])[CH3:19].C([O-])(=O)C.[Pb+2].C([O-])(=O)C.C(=O)([O-])[O-].[Na+].[Na+]>C(O)(=O)C>[O:17]=[C:13]1[C:14]2[C:10](=[CH:9][C:8]([O:7][CH2:6][C@H:2]3[CH2:3][CH2:4][CH2:5][O:1]3)=[CH:16][CH:15]=2)[CH2:11][CH:12]1[O:21][C:18](=[O:20])[CH3:19]

Komponenten

6

Edukt 4

HCID 7918Acetic AnhydrideHCID 9317Lead diacetateHCID 10340Sodium CarbonateHCID 689893065-[(R)-1-(tetrahydrofuran-2-yl)methoxy]-indan-1-one

Produkt 1

HCID 68991904HCID 68991904, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

A mixture of 5-[(R)-1-(tetrahydrofuran-2-yl)methoxy]-indan-1-one (1.25 g), acetic anhydride (3 mL), lead acetate (3.58 g) and acetic acid (3 mL) was stirred for 48 h at 100° C. After adding sodium carbonate solution it was extracted with ether, dried over magnesium sulfate and concentrated. The residue was chromatographed on silica gel. In this way the product was obtained with molecular weight 290.32 (C16H18O5); MS (ESI): 291 (M+H+).

Aufarbeitung

  1. extractionwas extracted with ether
  2. dry with materialdried over magnesium sulfate
  3. concentrationconcentrated
  4. customThe residue was chromatographed on silica gel
  5. customIn this way the product was obtained with molecular weight 290.32 (C16H18O5)

Quellen und Nachweise

ORD-Eintrag
ord-c20828727c024484b3872a5e0f98f411
Quelldatensatz
uspto-grants-2014_09
Patentnummer
US08822495B2

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