Peracetic Acid → HCID 14607966, Verbindung

HRID 724751Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 724751
[CH3:1][O:2][C:3](=[O:10])[CH2:4][C:5]1[CH2:9][CH2:8][CH2:7][CH:6]=1.C([O-])(=[O:13])C.[Na+].C(OO)(=O)C>C(Cl)(Cl)Cl.C(O)(=O)C>[CH3:1][O:2][C:3](=[O:10])[CH2:4][CH:5]1[CH2:9][CH:8]2[O:13][CH:7]2[CH2:6]1

Komponenten

6

Edukt 3

HCID 6585Peracetic AcidHCID 517045Sodium AcetateHCID 12282108Methyl (cyclopent-1-en-1-yl)acetate

Produkt 1

HCID 14607966HCID 14607966, VerbindungAusbeute 424,1 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 176Acetic AcidLösungsmittelHCID 6212ChloroformLösungsmittel

Reaktionsbedingungen

Temperatur
35 °C

Versuchsvorschrift

43.46 g (0.31 mol) of cyclopentenylacetic acid methyl ester are dissolved in 80 ml of chloroform. After the addition of 4 g of sodium acetate, 82.51 g of a 40% solution of peracetic acid in acetic acid are added dropwise thereto, with stirring, the temperature being maintained at about 35° C. The reaction mixture is then stirred for a further 5 hours at 35° C. The reaction mixture is extracted with 5% sodium hydrogen carbonate solution and then twice with water. The organic phase is then separated off and dried and residual peroxide is destroyed with sodium sulfite. After distillation of the organic phase there are obtained 32.3 g of 3,4-epoxycyclopentylacetic acid methyl ester (66.5% of theory).

Aufarbeitung

  1. additionare added dropwise
  2. stirringThe reaction mixture is then stirred for a further 5 hours at 35° C
  3. extractionThe reaction mixture is extracted with 5% sodium hydrogen carbonate solution
  4. customThe organic phase is then separated off
  5. customdried
  6. customresidual peroxide is destroyed with sodium sulfite
  7. distillationAfter distillation of the organic phase there

Quellen und Nachweise

ORD-Eintrag
ord-b52ae5b3f873495394226c06ff7b3f79
Quelldatensatz
uspto-grants-1998_01
Patentnummer
US05705316

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