Sodium Hydroxide → HCID 67021010, Verbindung

HRID 735441Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 735441
[CH3:1][C:2]1[CH:28]=[C:27]([CH3:29])[CH:26]=[CH:25][C:3]=1[CH2:4][N:5]1[C:13]([C:14]2[CH:19]=[CH:18][C:17]([F:20])=[CH:16][CH:15]=2)=[C:12]2[C:7]([C:8]([C:21](OC)=[O:22])=[CH:9][CH:10]=[CH:11]2)=[N:6]1.[Al].[Li].[H-].[OH-].[Na+].[O-]S([O-])(=O)=O.[Na+].[Na+]>C1COCC1.O>[CH3:1][C:2]1[CH:28]=[C:27]([CH3:29])[CH:26]=[CH:25][C:3]=1[CH2:4][N:5]1[C:13]([C:14]2[CH:15]=[CH:16][C:17]([F:20])=[CH:18][CH:19]=2)=[C:12]2[C:7]([C:8]([CH2:21][OH:22])=[CH:9][CH:10]=[CH:11]2)=[N:6]1

Komponenten

8

Edukt 5

HCID 14798Sodium HydroxideHCID 24436Sodium SulfateHCID 166653HydrideHCID 11696743HCID 11696743, VerbindungHCID 16211445Aluminum;lithium

Produkt 1

HCID 67021010HCID 67021010, VerbindungAusbeute 99,9 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittel2×HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

A solution of methyl 2-(2,4-dimethylbenzyl)-3-(4-fluorophenyl)-2H-indazole-7-carboxylate (0.100 g, 0.25 mmol) and lithium aluminum (0.1 g, 0.25 mmol) in 5 mL THF was stirred at ambient temperature for 1 hour. Excess hydride was decomposed by the addition of 0.1 mL H2O, 0.1 mL 1N NaOH, 0.3 mL H2O and 100 mg of Na2SO4. The solids were filtered and the filtrate concentrated in vacuo to give 0.09 g of product as a light yellow solid.

Aufarbeitung

  1. filtrationThe solids were filtered
  2. concentrationthe filtrate concentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-b736df336bb04641b9ffe336443096c1
Quelldatensatz
uspto-grants-2009_09
Patentnummer
US07592363B2

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