Reaktionsgleichung
S(F)(F)(F)[F:2].[CH2-]C(C)=O.[CH3:10][C:11]1[C:16]([OH:17])=[C:15]([CH2:18][OH:19])[C:14]([CH2:20]O)=[CH:13][N:12]=1.C(=O)=O.CC(C)=O.C(=O)=O.Cl>>[CH3:10][C:11]1[C:16]([OH:17])=[C:15]([CH2:18][OH:19])[C:14]([CH2:20][F:2])=[CH:13][N:12]=1Komponenten
Versuchsvorschrift
Sulfur tetrafluoride (41 mg.-mole) is passed into 40 ml. of liquid HF, cooled in a dry-ice-acetone bath, then, acetonide of 2-methyl-3-hydroxy-4-hydroxymethyl-5-hydroxymethyl pyridine, (4.18 g.; 20 mg.-mole) is added under continuing cooling. The dry-ice-acetone bath is not replenished with dry-ice and the mixture is left standing in it overnight. After blowing off the remaining HF at room temperature, conc. aq. HCl is added, evaporated to dryness in vacuo, the residue is redissolved in 20 ml. of 1M aq. HCl, heated on the steam-bath for 15 minutes, (for hydrolysis of the acetonide, charcoaled and evaporated to dryness, redissolved in water, then passed through a Dowex 50 × 2 cation-exchange resin column, washed free of F⃝ with water.
Aufarbeitung
- temperatureof liquid HF, cooled in a dry-ice-acetone bath
- temperatureunder continuing cooling
- waitthe mixture is left
- customstanding in it overnight
- customat room temperature
- customevaporated to dryness in vacuo
- dissolutionthe residue is redissolved in 20 ml
- temperatureof 1M aq. HCl, heated on the steam-bath for 15 minutes
- custom(for hydrolysis of the acetonide
- customevaporated to dryness
- dissolutionredissolved in water
- washwashed free of F⃝ with water
Quellen und Nachweise
- ORD-Eintrag
- ord-123d7525db764acab27efe24f1d2c49f
- Quelldatensatz
- uspto-grants-1978_06
- Patentnummer
- US04096180
Verknüpfte Notizen
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