Acetic Acid → N'-benzoyl-2-hydroxybenzohydrazide

HRID 844400

Reaktionsgleichung

Reaktionsgleichung von HRID 844400
[C:1]([NH:10][NH2:11])(=[O:9])[C:2]1[C:3](=[CH:5][CH:6]=[CH:7][CH:8]=1)[OH:4].C([O-])(=O)C.[Na+].C(O)(=O)C.[C:21](Cl)(=[O:28])[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1>O>[C:21]([NH:11][NH:10][C:1](=[O:9])[C:2]1[C:3](=[CH:5][CH:6]=[CH:7][CH:8]=1)[OH:4])(=[O:28])[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1

Komponenten

6

Edukt 4

HCID 176Acetic AcidHCID 7412Benzoyl chlorideHCID 13637Salicylic acid, hydrazideHCID 517045Sodium Acetate

Produkt 1

HCID 314231N'-benzoyl-2-hydroxybenzohydrazide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

A four neck flask (1 liter) equipped with a thermometer and a stirrer was charged with 60.8 g (0.4 mol) of salicylohydrazide, 49.2 g (0.6 mol) of sodium acetate and 700 ml of acetic acid. Dropwise added thereto was 67.4 g (0.48 mol) of benzoyl chloride in one hour while stirring, and stirring was continued at room temperature (20° C.) for 3 hours. After finishing the reaction, 1.5 liter of deionized water was added and crystal was filtered off. After washing sufficiently the crystal with 500 ml of methanol, it was dried under reduced pressure to obtain slightly brown crystal.

Aufarbeitung

  1. customA four neck flask (1 liter) equipped with a thermometer and a stirrer
  2. additionDropwise added
  3. customin one hour
  4. stirringstirring
  5. customwas continued at room temperature
  6. custom(20° C.)
  7. customfor 3 hours
  8. additionwas added
  9. filtrationcrystal was filtered off
  10. washAfter washing sufficiently the crystal with 500 ml of methanol, it
  11. customwas dried under reduced pressure
  12. customto obtain slightly brown crystal

Quellen und Nachweise

ORD-Eintrag
ord-b58a28837d2047a686fd6633db9a6adb
Quelldatensatz
uspto-grants-2002_04
Patentnummer
US06380288B1

Verknüpfte Notizen

Wird geladen…