Mannitol → Fentanyl

HRID 8554

Reaktionsgleichung

Reaktionsgleichung von HRID 8554
C(O)[C@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O.[CH3:13][CH2:14][C:15]([N:17]([CH:24]1[CH2:29][CH2:28][N:27]([CH2:30][CH2:31][C:32]2[CH:33]=[CH:34][CH:35]=[CH:36][CH:37]=2)[CH2:26][CH2:25]1)[C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=1)=[O:16].C(C(O)(C(O)=O)CC(O)=O)C(O)=O.COC([C@@H](NC([C@@H](N)CC(O)=O)=O)CC1C=CC=CC=1)=O>O>[CH3:13][CH2:14][C:15]([N:17]([CH:24]1[CH2:25][CH2:26][N:27]([CH2:30][CH2:31][C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=2)[CH2:28][CH2:29]1)[C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=1)=[O:16]

Komponenten

5

Edukt 3

HCID 6251MannitolHCID 13810Fentanyl CitrateHCID 134601Aspartame

Produkt 1

HCID 3345Fentanyl

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel2×

Versuchsvorschrift

Gelatin (765 g) and mannitol (540 g) were dispersed in a portion of purified water (16 kg) by mixing thoroughly in the bowl of a vacuum mixer. The mix was then heated to 40° C.±2° C. and homogenised for ten minutes to allow complete dissolution of the solids. The mix was cooled down to room temperature (20–24° C.). When cooled, the fentanyl citrate (22.68 g), the aspartame (90 g), and mint flavour (90 g) were added sequentially to the mix. The mix was then homogenized to ensure complete dissolution of the solids. The remaining water (492 g) was added to the mixer and the bulk mix homogenized to ensure dissolution was complete.

Aufarbeitung

  1. additionby mixing thoroughly in the bowl of a vacuum mixer
  2. temperatureThe mix was then heated to 40° C.±2° C.
  3. dissolutiondissolution of the solids
  4. temperatureWhen cooled
  5. stirringThe mix was then homogenized
  6. dissolutiondissolution of the solids
  7. additionthe bulk mix
  8. stirringhomogenized
  9. dissolutiondissolution

Quellen und Nachweise

ORD-Eintrag
ord-7699baaddd76414b851d402dc61a2e83
Quelldatensatz
uspto-grants-2006_08
Patentnummer
US07090866B2

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