Water → 4-(4-Nitroisothiazol-5-yl)morpholine

HRID 871042Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 871042
Br[C:2]1[S:6][N:5]=[CH:4][C:3]=1[N+:7]([O-:9])=[O:8].[NH:10]1[CH2:15][CH2:14][O:13][CH2:12][CH2:11]1.CCN(C(C)C)C(C)C.O>O1CCOCC1>[N+:7]([C:3]1[CH:4]=[N:5][S:6][C:2]=1[N:10]1[CH2:15][CH2:14][O:13][CH2:12][CH2:11]1)([O-:9])=[O:8]

Komponenten

6

Edukt 4

HCID 962WaterHCID 8083MorpholineHCID 81531DiisopropylethylamineHCID 126311735-Bromo-4-nitroisothiazole

Produkt 1

HCID 712617854-(4-Nitroisothiazol-5-yl)morpholine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

To a solution of 5-bromo-4-nitroisothiazole (P) (500 mg, 2.39 mmol) and morpholine (6B2) (620 mg, 7.12 mmol) in dioxane (10 mL) at room temperature (25° C.) was added DIEA (851 μL, 4.78 mmol). The solution was stirred for 30 min and HPLC showed the reaction was complete. Water (10 mL) was then added. A precipitate was formed, filtered and air dried at room temperature to get the product 6C6 (500 mg, 2.32 mmol).

Aufarbeitung

  1. customA precipitate was formed
  2. filtrationfiltered
  3. customair dried at room temperature
  4. customto get the product 6C6 (500 mg, 2.32 mmol)

Quellen und Nachweise

ORD-Eintrag
ord-1222045766594109a02eccc1ca989843
Quelldatensatz
uspto-grants-2015_03
Patentnummer
US08969584B2

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