Sodium Hydroxide → 1-(6-Chloropyrimidin-4-yl)azetidin-3-ol

HRID 876659Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 876659
Cl[C:2]1[N:7]=[C:6]([Cl:8])[CH:5]=[CH:4][N:3]=1.Cl.[OH:10][CH:11]1[CH2:14][NH:13][CH2:12]1.[OH-].[Na+]>O>[Cl:8][C:6]1[N:7]=[CH:2][N:3]=[C:4]([N:13]2[CH2:14][CH:11]([OH:10])[CH2:12]2)[CH:5]=1

Komponenten

5

Edukt 3

HCID 14798Sodium HydroxideHCID 775312,4-Dichloropyrimidine2×HCID 27592903-Hydroxyazetidine hydrochloride

Produkt 1

HCID 579250791-(6-Chloropyrimidin-4-yl)azetidin-3-olAusbeute 115,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

7.2 g (48.7 mmol) 2,4-dichloropyrimidine are initially introduced into 140 ml water. 5.3 g (48.7 mmol) 3-hydroxyazetidine hydrochloride and 48.7 ml 1 N sodium hydroxide solution are added and the mixture is heated at 90° C. for 72 h (the 2,4-dichloropyrimidine being detectably volatile and precipitating in crystalline form on the condenser). The solvent is removed in vacuo and the residue is dried to give 10.4 g of the crude product, which is reacted without further purification.

Aufarbeitung

  1. customprecipitating in crystalline form on the condenser)
  2. customThe solvent is removed in vacuo
  3. customthe residue is dried

Quellen und Nachweise

ORD-Eintrag
ord-5b075ba59a9b4b8082cb1b5a68c371b8
Quelldatensatz
uspto-grants-2015_03
Patentnummer
US08987261B2

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