Hydroxylamine → 6-Fluoro-1H-indole-3-carbonitrile

HRID 881591

Reaktionsgleichung

Reaktionsgleichung von HRID 881591
[F:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([CH:11]=O)=[CH:7][NH:8]2)=[CH:4][CH:3]=1.[NH2:13]O.C([O-])=O.[Na+].O>C(O)=O>[F:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([C:11]#[N:13])=[CH:7][NH:8]2)=[CH:4][CH:3]=1

Komponenten

6

Edukt 4

HCID 787HydroxylamineHCID 962WaterHCID 2629036-Fluoroindole-3-carboxaldehydeHCID 2723810Sodium Formate

Produkt 1

HCID 534187306-Fluoro-1H-indole-3-carbonitrileAusbeute 59,9 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 284Formic AcidLösungsmittel

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

To a solution of 6-fluoro-1H-indole-3-carbaldehyde (0.97 g) in 90% formic acid (25 mL) were added hydroxylamine (0.65 g) and sodium formate (0.81 g), and this mixture was stirred at 100° C. for 3 hours. After cooling to ambient temperature, water was added to this reaction mixture and the precipitated solid was collected by filtration, and washed with water, dried to give the title compound (0.57 g).

Aufarbeitung

  1. temperatureAfter cooling to ambient temperature
  2. filtrationthe precipitated solid was collected by filtration
  3. washwashed with water
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-11fdc67df2884d8ab2d6e058689db283
Quelldatensatz
uspto-grants-2015_03
Patentnummer
US08993616B2

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