Sodium Hydroxide → HCID 59421144, Verbindung

HRID 883009Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 883009
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[C:13]([C:14]([O:16]CC)=O)=[CH:12][N:11]=[C:10]([S:19][CH3:20])[N:9]=1.[OH-].[Na+].C(Cl)(=O)C(Cl)=O.[CH3:29][O:30][C:31]1[CH:32]=[C:33]([CH:39]=[CH:40][CH:41]=1)[CH2:34][NH:35][CH:36]([CH3:38])[CH3:37].C(N(C(C)C)CC)(C)C>C(O)C.O.C(Cl)Cl.CN(C=O)C>[CH3:29][O:30][C:31]1[CH:32]=[C:33]([CH:39]=[CH:40][CH:41]=1)[CH2:34][N:35]([CH:36]([CH3:38])[CH3:37])[C:14]([C:13]1[C:8]([C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=2[F:1])=[N:9][C:10]([S:19][CH3:20])=[N:11][CH:12]=1)=[O:16]

Komponenten

10

Edukt 5

HCID 14798Sodium HydroxideHCID 65578Oxalyl chlorideHCID 81531DiisopropylethylamineHCID 17156044N-[(3-Methoxyphenyl)methyl]propan-2-amineHCID 59421256Ethyl 4-(2-fluorophenyl)-2-(methylthio)-5-pyrimidinecarboxylate

Produkt 1

HCID 59421144HCID 59421144, VerbindungAusbeute 23,5 %

Reagenzien, Katalysatoren, Lösungsmittel 4

HCID 702EthanolLösungsmittelHCID 962WaterLösungsmittelHCID 6228DimethylformamideLösungsmittelHCID 6344DichloromethaneLösungsmittel3×

Versuchsvorschrift

A mixture of ethyl 4-(2-fluorophenyl)-2-(methylthio)pyrimidine-5-carboxylate (3.3 g, 10.96 mmol), solid NaOH (3.2 g) in ethanol (30 mL) and water (6 mL) was refluxed for 1 h. and cooled to room temperature. The solvent was removed under reduced pressure, and the residue was acidified with 6N HCl. The product was extracted with EtOAC (3×50 mL), and the organic extracts were dried and concentrated to give crude acids (1.6 g). A solution of 2 M oxalyl chloride in CH2Cl2 (3.00 mL, 6 mmol) was added to a stirred solution of the crude acids (1.6 g) in CH2Cl2 (25 mL) and DMF (1 mL) at room temperature, and stirring continued for 15 min. A solution of N-(3-methoxybenzyl)propan-2-amine, (1.07 g, 6.00 mmol) in CH2Cl2 (2 mL) and diisopropylethylamine (2 mL, 12 mmol) was added and stirred for 1 hr. The solvent was removed under reduced pressure and the residue was purified by Biotage SP1 on packed silica gel column (10%-80% EtOAc/Hexanes gradient) to give N-(3-methoxybenzyl)-4-(2-fluorophenyl)-N-isopropyl-2(methylthio)pyrimidine-5-carboxamide (0.6 g, 13%). Mass Spec. FIA MS 426 (M+1).

Aufarbeitung

  1. temperaturewas refluxed for 1 h.
  2. customThe solvent was removed under reduced pressure
  3. extractionThe product was extracted with EtOAC (3×50 mL)
  4. customthe organic extracts were dried
  5. concentrationconcentrated
  6. customto give crude acids (1.6 g)
  7. customThe solvent was removed under reduced pressure
  8. customthe residue was purified by Biotage SP1

Quellen und Nachweise

ORD-Eintrag
ord-6e54520e814946a4adf666dafde522b2
Quelldatensatz
uspto-grants-2012_08
Patentnummer
US08236815B2

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