Diisopropylamine → Tert-butyl 5-(2,2-difluoro-1-hydroxyethyl)-2',4'-difluorobiphenyl-3-carboxylate

Reaktionsgleichung

Br[C:2]1[CH:3]=[C:4]([CH:12]=[C:13]([CH:15]([OH:19])[CH:16]([F:18])[F:17])[CH:14]=1)[C:5]([O:7][C:8]([CH3:11])([CH3:10])[CH3:9])=[O:6].[F:20][C:21]1[CH:26]=[C:25]([F:27])[CH:24]=[CH:23][C:22]=1B(O)O.C1C=C(S([O-])(=O)=O)C=C(P(C2C=CC=C(S([O-])(=O)=O)C=2)C2C=CC=C(S([O-])(=O)=O)C=2)C=1.[Na+].[Na+].[Na+].C(NC(C)C)(C)C>CN(C)C=O.O.[Cl-].[Na+].O.C([O-])(=O)C.[Pd+2].C([O-])(=O)C>[F:17][CH:16]([F:18])[CH:15]([C:13]1[CH:12]=[C:4]([C:5]([O:7][C:8]([CH3:11])([CH3:10])[CH3:9])=[O:6])[CH:3]=[C:2]([C:24]2[CH:23]=[CH:22][C:21]([F:20])=[CH:26][C:25]=2[F:27])[CH:14]=1)[OH:19]