2-Ethylcyclohexanone → 2-Ethyl-1-(hydroxyimino)cyclohexane

HRID 890364

Reaktionsgleichung

Reaktionsgleichung von HRID 890364
[CH2:1]([CH:3]1[CH2:8][CH2:7][CH2:6][CH2:5][C:4]1=O)[CH3:2].C([O-])(=O)C.[Na+].Cl.[NH2:16][OH:17]>O.C(O)C>[CH2:1]([CH:3]1[CH2:8][CH2:7][CH2:6][CH2:5][C:4]1=[N:16][OH:17])[CH3:2]

Komponenten

6

Edukt 3

HCID 204742-EthylcyclohexanoneHCID 443297Hydroxyamine hydrochlorideHCID 517045Sodium Acetate

Produkt 1

HCID 5746222-Ethyl-1-(hydroxyimino)cyclohexaneAusbeute 52 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 702EthanolLösungsmittelHCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
70 °C

Versuchsvorschrift

To a solution of 2-ethylcyclohexanone (104.3 mmol) in water and ethanol, and sodium acetate (125.1 mmol) were added hydroxylamine hydrochloride (156.4 mmol), the reaction was heated at 70° C. overnight. The ethanol was removed under reduced pressure, and the reaction mixture was dissolved in water. The aqueous layer was extracted with ether, and the combined organic extracts were washed with brine, dried over sodium sulfate, and concentrated to give 2-ethyl-1-(hydroxyimino)cyclohexane (52%) as a thick oil.

Aufarbeitung

  1. customThe ethanol was removed under reduced pressure
  2. dissolutionthe reaction mixture was dissolved in water
  3. extractionThe aqueous layer was extracted with ether
  4. washthe combined organic extracts were washed with brine
  5. dry with materialdried over sodium sulfate
  6. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-36d1fda336bd4efbb943c938ef9c8884
Quelldatensatz
uspto-grants-2006_02
Patentnummer
US06995269B2

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