Sodium Acetate → 3,5-Difluorotoluene

HRID 908241Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 908241
Br[CH2:2][C:3]1[CH:8]=[C:7]([F:9])[CH:6]=[C:5]([F:10])[CH:4]=1.C([O-])(=O)C.[Na+]>CCOCC.[Pd]>[F:9][C:7]1[CH:8]=[C:3]([CH3:2])[CH:4]=[C:5]([F:10])[CH:6]=1

Komponenten

5

Edukt 2

HCID 517045Sodium AcetateHCID 5188963,5-Difluorobenzyl bromide

Produkt 1

HCID 27783293,5-Difluorotoluene

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 3283Diethyl EtherLösungsmittel

Versuchsvorschrift

A mixture of 1-(bromomethyl)-3,5-difluorobenzene (50 g, 0.24 mol), 10% Pd/C (3 g) and sodium acetate (140 g, 1.7 mol) in anhydrous ether (250 mL) was stirred under hydrogen at atmospheric pressure for 24 hr. The mixture was filtered and the filtrate was dried over anhydrous Na2SO4, filtered and used directly in the next step. 1H-NMR (500 MHz, CDCl3): δ 6.56 (d, 2H, J=6.0 Hz), 6.47 (t, 1H, J=9.0 Hz), 2.22 (s, 3H).

Aufarbeitung

  1. filtrationThe mixture was filtered
  2. dry with materialthe filtrate was dried over anhydrous Na2SO4
  3. filtrationfiltered

Quellen und Nachweise

ORD-Eintrag
ord-142d52581a6f4ee5a4b9467cfba32377
Quelldatensatz
uspto-grants-2011_09
Patentnummer
US08017605B2

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