Acetic Acid → HCID 67382248, Verbindung

HRID 910203Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 910203
[CH3:1][C:2]1[S:12][C:5]2[NH:6][C:7](=[O:11])[NH:8][C:9](=[O:10])[C:4]=2[CH:3]=1.C(O)(=O)C.[Br:17]Br>O>[Br:17][C:3]1[C:4]2[C:9](=[O:10])[NH:8][C:7](=[O:11])[NH:6][C:5]=2[S:12][C:2]=1[CH3:1]

Komponenten

5

Edukt 3

HCID 176Acetic AcidHCID 24408BromineHCID 127242076-Methylthieno[2,3-d]pyrimidine-2,4(1H,3H)-dione

Produkt 1

HCID 67382248HCID 67382248, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

A brown glass round-bottom flask was charged with 6-methyl-1H-thieno[2,3-d]pyrimidine-2,4-dione (2.70 g, 14.8 mmol) and glacial acetic acid (30 ml). Bromine (2.70 ml) was added and the mixture stirred at ambient temperature for 4 hours. The resultant mixture was diluted with water (30 ml) and the solid was collected by filtration, washed thoroughly with water and then dried in vacuo to give 5-bromo-6-methyl-1H-thieno[2,3-d]pyrimidine-2,4-dione as a brown solid (2.43 g), which was used without further purification.

Aufarbeitung

  1. filtrationthe solid was collected by filtration
  2. washwashed thoroughly with water
  3. customdried in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-cfa9fdeba9e34fe7ad6cdc06a7a0cf0c
Quelldatensatz
uspto-grants-2011_09
Patentnummer
US08022076B2

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