Ammonia → 2-Benzothiazolamine, 6-bromo-

Temperatur

50 °C

A solution of N-(4-bromophenyl)thiourea (16.18 g) and magnesium oxide (1.41 g) in chlorobenzene (100 mL) was heated to 50° C., and a solution of sulfuryl chloride (8.43 mL) in chlorobenzene (9 mL) was added dropwise to the solution over 1 hour or longer, followed by stirring at 50° C. overnight. The reaction mixture was returned to room temperature, and water (20 mL) was added thereto. The pH of the mixture was adjusted to about 8 by use of concentrated aqueous ammonia, and the precipitates were recovered through filtration. The obtained solid was recrystallized from 90% ethanol, to thereby yield the title compound (7.95 g).

1. customwas returned to room temperature
2. filtrationthe precipitates were recovered through filtration
3. customThe obtained solid was recrystallized from 90% ethanol

ORD-Eintrag

ord-b0fd9dd3609b43099be2bb67858921e4

Quelldatensatz

uspto-grants-2011_09

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US08022075B2