Propyl Gallate → Thyroxine

HRID 918791

Reaktionsgleichung

Reaktionsgleichung von HRID 918791
C(O)[C@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O.C(O)[C@H]1O[C@H](O[C@]2(CO)O[C@H](CO)[C@@H](O)[C@@H]2O)[C@H](O)[C@@H](O)[C@@H]1O.[CH:36]1[C:37]([CH2:54][C@H:55]([NH2:59])[C:56]([O-:58])=[O:57])=[CH:38][C:39]([I:53])=[C:40]([O:43][C:44]2[CH:45]=[C:46]([I:52])[C:47]([OH:51])=[C:48]([I:50])[CH:49]=2)[C:41]=1[I:42].O.[Na+].C(OCCC)(=O)C1C=C(O)C(O)=C(O)C=1>O>[CH:38]1[C:37]([CH2:54][C@H:55]([NH2:59])[C:56]([OH:58])=[O:57])=[CH:36][C:41]([I:42])=[C:40]([O:43][C:44]2[CH:49]=[C:48]([I:50])[C:47]([OH:51])=[C:46]([I:52])[CH:45]=2)[C:39]=1[I:53]

Komponenten

6

Edukt 4

HCID 4947Propyl GallateHCID 5988SucroseHCID 6251MannitolHCID 23667619Levothyroxine sodium monohydrate

Produkt 1

HCID 5819Thyroxine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

The microcrystalline cellulose, mannitol, and sucrose were screened or milled and then blended with levothyroxine sodium for about 6 minutes. Acacia, dissolved in water, and propyl gallate, dissolved in alcohol, were added over about 10 minutes to granulate the mixture. The wet granulation was dried at a temperature below 60° C. until the moisture content was less than about 4%. The dried granulation was sized by passing it through a mill, and then blended with the additional ingredients listed in the table below using conventional mixing equipment.

Aufarbeitung

  1. custommilled
  2. additionwere added over about 10 minutes
  3. customThe wet granulation was dried at a temperature below 60° C. until the moisture content

Quellen und Nachweise

ORD-Eintrag
ord-0bd877d47e864390a12d8cb9751902d4
Quelldatensatz
uspto-grants-2016_03
Patentnummer
US09271951B2

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