1,2-Dichloroethane → HCID 66685531, Verbindung

To a 100 mL RB flask fitted with magnetic stirrer was charged with 10 mL of 1,2-dichloroethane. To the stirring solution were added 3-methyl-5-(4-nitrophenyl)-1,2-oxazole (0.27 g, 1.30 mmol), N-iodosuccinimide (0.28 g, 1.24 mmol), followed by concentrated H2SO4 (0.2 mL) at 0° C. and stirred at room temperature for 4 h. The reaction mixture was poured into water (30 mL) and extracted with ethyl acetate (50 mL). The organic layer was washed with sodium thiosulphate solution (30 mL), water (30 mL) and saturated brine solution (10 mL). The organic layer was dried over anhydrous Na2SO4 and the solvent was removed under reduced pressure. The product was obtained as yellow solid (0.40 g, yield: 93.7%). 1H NMR (300 MHz, CDCl3): δ 8.29-8.32 (dd, 2H), 8.18-8.21 (dd, 2H), 2.33 (s, 3H).

1. customTo a 100 mL RB flask fitted with magnetic stirrer
2. extractionextracted with ethyl acetate (50 mL)
3. washThe organic layer was washed with sodium thiosulphate solution (30 mL), water (30 mL) and saturated brine solution (10 mL)
4. dry with materialThe organic layer was dried over anhydrous Na2SO4
5. customthe solvent was removed under reduced pressure

ORD-Eintrag

ord-fda15d37112f4d62a8fe5323a8e6e953

Quelldatensatz

uspto-grants-2016_03

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US09278915B2