Carbon Dioxide → 5-Benzoxy-2,3,4-trifluorobenzoic acid
Reaktionsgleichung
[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([F:15])=[C:11]([F:16])[C:10]=1[F:17])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Li+].CC([N-]C(C)C)C.[Li]CCCC.[C:31](=[O:33])=[O:32]>>[CH2:1]([O:8][C:9]1[C:10]([F:17])=[C:11]([F:16])[C:12]([F:15])=[C:13]([CH:14]=1)[C:31]([OH:33])=[O:32])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1Komponenten
5
Versuchsvorschrift
To a solution of 1-benzyloxy-2,3,4-trifluorobenzene in appropriate inert solvent is added strong base (such as LDA, n-BuLi, LiHDMS) at low temperature (−50-−80° C., prefer −78° C.) under nitrogen atmosphere. The stirring is maintained at this temperature for several hours (0.5-12 h, prefer 0.5-2 h). The mixture is transferred to a bottle with dry ice and the resulting mixture is stirred for some time (such as 3-12 h, prefer 5-10 h). 5-Benzoxy-2,3,4-trifluorobenzoic acid is obtained after conventional workup.
Aufarbeitung
- temperatureThe stirring is maintained at this temperature for several hours (0.5-12 h, prefer 0.5-2 h)
Quellen und Nachweise
- ORD-Eintrag
- ord-444acb7a255c43a1b7b032102210ba5e
- Quelldatensatz
- uspto-grants-2016_03
- Patentnummer
- US09290468B2
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