Bromine → 6-Amino-5-bromopyridine-3-carbonitrile

HRID 931040

Reaktionsgleichung

Reaktionsgleichung von HRID 931040
[NH2:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][N:3]=1.[Br:10]Br>C(O)(=O)C>[NH2:1][C:2]1[C:9]([Br:10])=[CH:8][C:5]([C:6]#[N:7])=[CH:4][N:3]=1

Komponenten

4

Edukt 2

HCID 24408BromineHCID 8182602-Amino-5-cyanopyridine

Produkt 1

HCID 14912506-Amino-5-bromopyridine-3-carbonitrile

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

To a solution of 6-aminonicotinonitrile (5.0 g) in acetic acid (50 mL) was added bromine (4.3 mL) under ice-cooling. The reaction mixture was stirred at room temperature for 3 days, and the precipitate was collected by filtration. The obtained solid was suspended in ethyl acetate and IPE, and collected by filtration to give the title compound (8.2 g).

Aufarbeitung

  1. temperaturecooling
  2. filtrationthe precipitate was collected by filtration
  3. filtrationIPE, and collected by filtration

Quellen und Nachweise

ORD-Eintrag
ord-c37ee5a966f84b3ba9f10a38389ad20d
Quelldatensatz
uspto-grants-2016_03
Patentnummer
US09296746B2

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