Water → 1-{(4R)-1-benzyl-4-(t-butyldimethylsilyloxy) pyrrolidin-2-yl}-1-[1-methylimidazol-2-yl]methanol

To a solution of N-methylimidazole (84.0 ml) in tetrahydrofuran (1.25 l) was added dropwise n-butyllithium (1.56N, 500 ml and 1.60N, 120 ml) in hexane keeping the temperature below -65° C. After stirring for 30 minutes, to the mixture was added dropwise a solution of (2S,4R)-1-benzyl-4-(t-butyldimethylsilyloxy)-2-formylpyrrolidine (259 g) in THF (1.25 l) at -65°~-60° C. for 30 minutes. The mixture was stirred at -60°~0° C. for 1.5 hours and at 0°~5° C. for 30 minutes. The reaction mixture was poured into a mixture of cold water (5 l) and ethyl acetate (5 l). The organic layer was separated, washed with water and brine, dried over magnesium sulfate and evaporated under reduced pressure. To the residue was added ethyl acetate (180 ml) and n-hexane (620 ml). The precipitate was collected by filtration to give isomer A of 1-{(4R)-1-benzyl-4-(t-butyldimethylsilyloxy) pyrrolidin-2-yl}-1-[1-methylimidazol-2-yl]methanol (480 g). The filtrate was evaporated in vacuo. The residue was chromatographed on silica gel (2.6 kg, eluent; AcOEt:n-hexan=3:2 to 10:0), and the eluate was evaporated to give isomer B of the same (147.4 g) containing 17% of isomer A, as a solid.

1. stirringThe mixture was stirred at -60°~0° C. for 1.5 hours and at 0°~5° C. for 30 minutes
2. customThe organic layer was separated
3. washwashed with water and brine
4. dry with materialdried over magnesium sulfate
5. customevaporated under reduced pressure
6. additionTo the residue was added ethyl acetate (180 ml) and n-hexane (620 ml)
7. filtrationThe precipitate was collected by filtration

ORD-Eintrag

ord-c9739adbf96e4904a76e840f98d61a55

Quelldatensatz

uspto-grants-1997_03

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US05608056