Magnesium Sulfate Heptahydrate

HCID 24843

Basic information

CAS
10034-99-8
Standard SMILES
O.O.O.O.O.O.O.O=S(=O)([O-])[O-].[Mg+2]
InChIKey
WRUGWIBCXHJTDG-UHFFFAOYSA-L
Molecular formula
Mg.S.O4.7H2O
Average molar mass
246.48 g/mol
Monoisotopic mass
246.01072397

Overview

Magnesium sulfate heptahydrate is a hydrate that is the heptahydrate form of magnesium sulfate. It has a role as a laxative and a cathartic. It is a magnesium salt and a hydrate. It contains a magnesium sulfate.

Names & identifiers

Preferred name
Magnesium Sulfate Heptahydrate
IUPAC
magnesium;sulfate;heptahydrate
English name
Magnesium sulfate heptahydrate
Molecular formula
Mg.O4S.7H2O
Molecular weight
246.47

Names & synonyms

Magnesium sulfate heptahydrate10034-99-8Epsom saltmagnesium sulphate heptahydrateMagnesia sulphuricaMagnesium sulfate (1:1) heptahydrateEpsom salt(heptahydrate)Bitter saltSulfuric acid magnesium salt (1:1), heptahydrateSK47B8698TMagnesii sulfatis heptahydrasCHEBI:31795
Show more names
MgSOEPSOM SALTSSULFURIC ACID MAGNESIUMMagnesiumsulfatMAGNESIUM SULFATE 7HYD XTLMAGNESIUM SULPHATE 7-HYDRATECrystalline magnesium sulfateMagnesium sulfate heptahydrate, 99%, for analysis
Magnesium Sulfate, HeptahydrateTheraworx ReliefHumco Epson SaltCVS muscle reliefRelief Epsom SaltNuValu Epsom SaltAssured Epsom SaltEpsom Salts Relief

Database identifiers

CAS
10034-99-8、14457-55-7
PubChem CID
24843
DTXSID
DTXSID5040544
ChEBI
CHEBI:31795
UNII
SK47B8698T
EC Number
600-073-4、913-387-4

Properties

Computed structural properties

Topological polar surface area
95.6 Ų
Hydrogen bond donors
7
Hydrogen bond acceptors
11
Rotatable bonds
0
Heavy atoms
13

Experimental & physicochemical properties

Density1.68 @25 °C
Physical DescriptionLiquid; Large Crystals; Dry Powder

Physicochemical properties

Melting point
1124 °C · 1124°C
Density
2.66 · 2.66
bulk density
900 kg/m3 · 900kg/m3
vapor density
0.01 · <0.01 (vs air)
vapor pressure
0.1 mm · <0.1 mm Hg ( 20 °C)
refractive index
1.433 · 1.433

Safety & regulation

GHS classification

GHS Classification · 6 items

This chemical does not meet GHS hazard criteria for 100% (424 of 424) of all reports.

Not Classified

Aggregated GHS information provided per 424 reports by companies from 2 notifications to the ECHA C&L Inventory.

This chemical does not meet GHS hazard criteria for 100% (2 of 2) of all reports.

Not Classified

Aggregated GHS information provided per 2 reports by companies from 1 notifications to the ECHA C&L Inventory.

Hazard information

Regulatory Information · 3 items

Chemical: Sulfuric acid, magnesium salt, heptahydrate

Sulfuric acid magnesium salt (1:1), heptahydrate is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Sulfuric acid magnesium salt (1:1), heptahydrate are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Sulfuric acid magnesium salt (1:1), heptahydrate: Does not have an individual approval but may be used under an appropriate group standard

Other Safety InformationIMAP assessments - Sulfuric acid, magnesium salt, heptahydrate: Human health tier I assessment
EPA Safer ChemicalChemical: Magnesium sulfate, heptahydrate
Hazard Classes and Categories · 2 items

Not Classified

Not Classified

Safety & protection

Protective Action Criteria (PAC) · 3 items

1.2 [mg/m3]

13 [mg/m3]

81 [mg/m3]

Safety data

wgk
1
tsca
Yes
rtecs
OM4508000
hs_code
28332100
Toxicity
man,TDLo,oral,183mg/kg/4H-I (183mg/kg),GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA",Journal of Toxicology, Clinical Toxicology. Vol. 20, Pg. 107, 1983.
risk_code
36/37/38

Chemistry & industry

Pharmacology

FDA Pharmacological Classification · 6 items

50% MAGNESIUM SULFATE

Increased Large Intestinal Motility [PE]; Stimulation Large Intestine Fluid/Electrolyte Secretion [PE]; Inhibition Small Intestine Fluid/Electrolyte Absorption [PE]; Magnesium Ion Exchange Activity [MoA]; Osmotic Laxative [EPC]; Inhibition Large Intestine Fluid/Electrolyte Absorption [PE]; Osmotic Activity [MoA]; Calculi Dissolution Agent [EPC]

EPSOM SALT

Calculi Dissolution Agent [EPC]; Osmotic Activity [MoA]; Inhibition Large Intestine Fluid/Electrolyte Absorption [PE]; Osmotic Laxative [EPC]; Magnesium Ion Exchange Activity [MoA]; Inhibition Small Intestine Fluid/Electrolyte Absorption [PE]; Stimulation Large Intestine Fluid/Electrolyte Secretion [PE]; Increased Large Intestinal Motility [PE]

MAGNESIA SULPHURICA

Calculi Dissolution Agent [EPC]; Osmotic Activity [MoA]; Inhibition Large Intestine Fluid/Electrolyte Absorption [PE]; Osmotic Laxative [EPC]; Magnesium Ion Exchange Activity [MoA]; Inhibition Small Intestine Fluid/Electrolyte Absorption [PE]; Stimulation Large Intestine Fluid/Electrolyte Secretion [PE]; Increased Large Intestinal Motility [PE]

MeSH Pharmacological Classification · 6 items

Compounds capable of relieving pain without the loss of CONSCIOUSNESS.

Agents capable of inducing a total or partial loss of sensation, especially tactile sensation and pain. They may act to induce general ANESTHESIA, in which an unconscious state is achieved, or may act locally to induce numbness or lack of sensation at a targeted site.

Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade.

Drugs used to prevent SEIZURES or reduce their severity.

A class of drugs that act by selective inhibition of calcium influx through cellular membranes.

Drugs that prevent preterm labor and immature birth by suppressing uterine contractions (TOCOLYSIS). Agents used to delay premature uterine activity include magnesium sulfate, beta-mimetics, oxytocin antagonists, calcium channel inhibitors, and adrenergic beta-receptor agonists. The use of intravenous alcohol as a tocolytic is now obsolete.

Uses & manufacturing

U.S. Production2023: 250,000 - <400,000 lb
Consumer UsesSoil amendments (fertilizers)
Industry UsesFlocculating agent
Household ProductsInformation on 24 consumer products that contain Magnesium sulfate heptahydrate in the following categories is provided:
Use Classification · 2 items

EPA Safer Chemical Functional Use Classes -> Processing Aids and Additives

Safer Chemical Classes -> Green circle - The chemical has been verified to be of low concern

General Manufacturing InformationPesticide, Fertilizer, and Other Agricultural Chemical Manufacturing
Applications · 6 items

Uses1. It can be used for catharsis with its saturated solution subject to topical administration. It has anti-inflammatory, detumescence, detoxification, analgesic effect, and can inhibit the effect of central nervous system, anti-traction and antispasmodic; used as the weighing agent of printing fine cotton, cotton, silk and the filler for kapok products; it can be used for the manufacturing of grass, fertilizers, porcelain, pigments, matches, explosives and fireproof materials; can be used as the medium component in the microbial industry; supplying the magnesium for brewing additives; used as filler to enhance the thermal resistance in the leather industry; used for the production of fresh yeast, monosodium glutamate and the stabilizer of dicalcium phosphate used in toothpaste production; can also be used in cement coagulant; pulp industry, rayon and silk industry, etc. Product containing a small amount of crystal water or no crystal water can be used for the synthesis of product that contains low water content and mixed ingredients. In organic chemical industry, it can be used for desiccant and dehydrating agent for printing thin cotton, silk, as the aggravating agent of cotton and filler of kapok products. 2. It can be used for leather industry, fertilizer, porcelain, matches, explosives, printing and dyeing, pharmaceutical and other industries 3. It can be used for steelmaking and ironmaking 4. Magnesium sulfate is a feed nutrition enhancer. 5. It can be used as laxative, cholagogue, for cathartic and duodenal diversion 6. It can be used as analysis reagents and mordant 7. It can be used as food fortifier. China provides that it can be used for dairy products with the usage amount of 3~7 g/kg; usage amount in the beverages and milk beverages is 1.4~2.8g/kg; the maximum dose in mineral drinks should be 0.05g/kg. 8. It can be used as nutritional supplements, curing agents, flavor enhancers, processing aids. Brewing additives for supplement the magnesium of brewing water; as a source of nutrients during fermentation to enhance the fermentation capacity; improve the flavor of synthetic wine (usage amount of 0.002%). Adjust the water hardness. In Europe for the production of "Bolton" type of beer. 9. It is often used in combination with the calcium salt for the yeast-purpose water. Addition of 4.4g/100 water being able to increase the hardness of 1 degree with multi-use producing bitter and producing hydrogen sulfide odor. 10. This product can be used as tanning filler. In the printing and dyeing industry, it can be used as the aggravating agent of the thin cotton. Used as paper sizing agent. 11. U

DescriptionIn addition to its use in foods as a flavor enhancer, nutrient supplement and processing aid, magnesium sulfate (as Epsom salt) is employed in over-the-counter preparations as a laxative. As a legend (prescription drug) it has been used as an anticonvulsant and electrolyte replenisher.

UsesUsed in preparation of magnesium standard solutions

UsesMagnesium Sulfate is a nutrient and dietary supplement. It is soluble in water and its solutions are neutral. It exists as crystals with a cooling, saline, bitter taste. It is also termed epsom salt.

UsesMagnesium sulfate heptahydrate has been used:as a component in Kreb′s Ringer bufferas a component in minimal medium to culture Ralstonia solanacearumin the preparation of maceration solution for Lamb′s lettuce cell isolation and isotonic glucose buffer

General DescriptionMagnesium sulfate heptahydrate is hydroscopic and is vulnerable to warm temperatures.

Suppliers100 total

国药集团化学试剂有限公司86-21-63210123 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
上海麦克林生化科技股份有限公司021-50706066 15221275939 · [email protected]
河北永泰供应链管理有限公司15130657697 15130657697 · [email protected]
上海毕合生物化学技术有限公司13816464724 · [email protected]

Additional notes

DefinitionEpsomite: a mineral form of magnesiumsulphate heptahydrate,MgSO4.7H2O.

Related reactions

28 records

Compound notes

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