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4-Toluenesulfonyl chloride → N-(4-iodophenyl)-4-methylbenzenesulfonamide

HRID 1031278
Notes
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Reaction equation

HRID 1031278 reaction equation
Cc1ccc(S(=O)(=O)Cl)cc1.Nc1ccc(I)cc1>CC(C)=O.O.O=C([O-])O.OCCOCCOCCOCCOCCO.[Na+]>Cc1ccc(S(=O)(=O)Nc2ccc(I)cc2)cc1
ParticipantsConditionsWorkupSources & evidenceReaction notes

Participants

7

Reactant 2

HCID 73974-Toluenesulfonyl chlorideHCID 108934-Iodoaniline

Product 1

HCID 293628N-(4-iodophenyl)-4-methylbenzenesulfonamideYield 90%

Reagents, catalysts & solvents 4

HCID 516892Sodium BicarbonateReagentHCID 180AcetoneSolventHCID 962WaterSolventHCID 62551Pentaethylene glycolSolvent

Conditions

Temperature
25 °C

Workup

  1. additionNo procedure recorded
  2. extractionKeep organic
  3. washNo procedure recorded
  4. washNo procedure recorded
  5. dry with materialNo procedure recorded
  6. concentrationNo procedure recorded

Sources & evidence

ORD record
ord-00b28c352e6a453398fad16ac35a55c6
Source dataset
39 compound library from "Building a Sulfonamide Library by Eco-Friendly Flow Synthesis"
DOI
10.1021/co400012m
Original link
View source

Reaction notes

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On this pageParticipantsConditionsWorkupSources & evidenceReaction notes