Furfural → 2-(1-Hydroxy-2-methyl-3-butynyl)-furan

Temperature

10 °C

In the same flask as in Example 1, there were charged granular magnesium (18.2 g), dry zinc chloride (10.2 g) and dry tetrahydrofuran (100 g). 3-Chloro-1-butyne (0.66 g) was added thereto at 10° C. while stirring. The resultant mixture was kept in an adiabatic condition, whereupon the reaction proceeded. When the best generation stopped, a mixture of furfural (48 g), 3-chloro-1-butyne (45.88 g) and toluene (125 g) was dropwise added to the reaction mixture at 45° C. in 1.5 hours while stirring under cooling. The resultant mixture was kept at room temperature for 30 minutes while stirring. After completion of the reaction, the reaction mixture was treated in the same manner as in Example 1 and distilled under reduced pressure (66°-68° C./1 mmHg) to give 2-(1-hydroxy-2-methyl-3-butynyl)-furan (63.8 g) in a yield of 84% (based on the starting furfural).

1. additionwas dropwise added to the reaction mixture at 45° C. in 1.5 hours
2. stirringwhile stirring
3. temperatureunder cooling
4. stirringwhile stirring
5. customAfter completion of the reaction
6. additionthe reaction mixture was treated in the same manner as in Example 1
7. distillationdistilled under reduced pressure (66°-68° C./1 mmHg)

ORD record

ord-27e9a925e245409d9bffe5902e8183c1

Source dataset

uspto-grants-1990_09

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US04958033