Hydrochloric Acid → (2',4',6'-Triisopropylbiphenyl-2-yl)phosphine

Temperature

0 °C

A solution of ethyl 2′,4′,6′-triisopropylbiphenyl-2-ylphosphinate (17.5 g, 47.0 mmol, 1.0 equiv) in 100 mL of anhydrous, degassed THF was cooled to 0° C. under an atmosphere of nitrogen. The lithium aluminum hydride/chlorotrimethylsilane solution was transferred by cannula into the solution of phosphinate over 20 min. The reaction was allowed to proceed overnight with slow warming to 22° C. Prior to quench the mixture was cooled in an ice bath. The reaction was quenched by slow addition of EtOAc (23 mL, 235 mmol, 5 equiv), followed by aqueous hydrochloric acid (2 M, 250 mL, 500 mmol, 10.6 equiv). This mixture was allowed to stir for 1 h under an atmosphere of N2. This mixture was diluted with EtOAc (250 mL), the layers were separated and the organic layer was washed once with a saturated solution of NaCl (100 mL). The organic solution was concentrated in vacuo to give a white solid (23.0 g) which was 66% potent (w/w by HPLC), for a 99% yield. This material was used without further purification.

1. temperaturewith slow warming to 22° C
2. customPrior to quench the mixture
3. temperaturewas cooled in an ice bath
4. customthe layers were separated
5. washthe organic layer was washed once with a saturated solution of NaCl (100 mL)
6. concentrationThe organic solution was concentrated in vacuo

ORD record

ord-f70791f56bf64f4cb052691f1999c68f

Source dataset

uspto-grants-2016_07

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US09381508B2