Dichloromethane → Diisopropylethylamine

Reaction equation

C(O)(=O)C[CH2:3][C:4]([CH3:6])=O.[CH3:9][CH:10]([CH3:17])[N:11]=[C:12]=NC(C)C.[CH2:18](Cl)Cl>>[CH3:18][CH2:12][N:11]([CH:4]([CH3:3])[CH3:6])[CH:10]([CH3:17])[CH3:9]

Participants

Reactant 3

HCID 6344Dichloromethane

HCID 11579Levulinic Acid

HCID 12734Diisopropylcarbodiimide

Product 1

HCID 81531Diisopropylethylamine

Procedure

addition of activated levulinic acid (activated as the symmetric anhydride with 0.5 equivalents of DIC in DCM for 5-10 min)

Sources & evidence

ORD record: ord-ffec451764134a1db4236c62aaba0bd9
Source dataset: uspto-grants-2006_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07094871B2

Reaction notes

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