Toluene → 6-[2-(2,4-Difluorophenyl)ethynyl]-3-nitro-pyridin-2-amine

Reaction equation

[C:19](#[CH:20])[c:21]1[c:22]([F:28])[cH:23][c:24]([F:27])[cH:25][cH:26]1.[CH3:12][CH2:13][N:14]([CH2:15][CH3:16])[CH2:17][CH3:18].[CH3:29][c:30]1[cH:31][cH:32][cH:33][cH:34][cH:35]1.[CH3:36][C:37]#[N:38].[Cl:1][c:2]1[cH:3][cH:4][c:5]([N+:9](=[O:10])[O-:11])[c:6]([NH2:8])[n:7]1.[Cu:39][I:40]>>[c:2]1([C:20]#[C:19][c:21]2[c:22]([F:28])[cH:23][c:24]([F:27])[cH:25][cH:26]2)[cH:3][cH:4][c:5]([N+:9](=[O:10])[O-:11])[c:6]([NH2:8])[n:7]1

Participants

Reactant 6

HCID 1140Toluene

HCID 6342Acetonitrile

HCID 8471Triethylamine

HCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)

HCID 27240356-Chloro-3-nitropyridin-2-ylamine

HCID 50638201-Ethynyl-2,4-difluorobenzene

Product 1

Sources & evidence

ORD record: ord-d3363164e2f9414d903938cb1948226a
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (7/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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