Benzyl Bromide → 2-(Benzyloxy)-5-bromobenzonitrile

HRID 1160807Notes

Reaction equation

HRID 1160807 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([OH:10])=[C:6]([CH:9]=1)[C:7]#[N:8].[CH2:11](Br)[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[CH2:11]([O:10][C:5]1[CH:4]=[CH:3][C:2]([Br:1])=[CH:9][C:6]=1[C:7]#[N:8])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

Participants

5

Reactant 3

HCID 7498Benzyl BromideHCID 11430Potassium CarbonateHCID 27570145-Bromo-2-hydroxybenzonitrile

Product 1

HCID 22377852-(Benzyloxy)-5-bromobenzonitrile

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

5-Bromo-2-hydroxybenzonitrile, benzyl bromide and potassium carbonate were reacted in DMF at room temperature to obtain 2-(benzyloxy)-5-bromobenzonitrile. EI: 287, 289.

Sources & evidence

ORD record
ord-a022a0e4658a4a37856f72ce197ffdf2
Source dataset
uspto-grants-2010_10
Patent number
US07816558B2

Reaction notes

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