Dimethylformamide → 2-Chloro-6-(hydroxymethyl)-4-vinylpyridin-3-ol

HRID 1205232

Reaction equation

HRID 1205232 reaction equation
[CH3:26][CH2:27][O:28][C:29]([CH3:30])=[O:31].[CH:12](=[CH2:13])[Sn:14]([CH:15]=[CH2:16])([CH:17]=[CH2:18])[CH:19]=[CH2:20].[Cl:1][c:2]1[n:3][c:4]([CH2:10][OH:11])[cH:5][c:6]([I:9])[c:7]1[OH:8].[O:21]=[CH:22][N:23]([CH3:24])[CH3:25].[Pd:32]([Cl:33])[Cl:34].[c:35]1([P:36]([c:37]2[cH:38][cH:39][cH:40][cH:41][cH:42]2)[c:43]2[cH:44][cH:45][cH:46][cH:47][cH:48]2)[cH:49][cH:50][cH:51][cH:52][cH:53]1.[c:54]1([P:55]([c:56]2[cH:57][cH:58][cH:59][cH:60][cH:61]2)[c:62]2[cH:63][cH:64][cH:65][cH:66][cH:67]2)[cH:68][cH:69][cH:70][cH:71][cH:72]1>>[Cl:1][c:2]1[n:3][c:4]([CH2:10][OH:11])[cH:5][c:6]([CH:12]=[CH2:13])[c:7]1[OH:8]

Participants

7

Reactant 6

HCID 6228DimethylformamideHCID 8857Ethyl AcetateHCID 11776Triphenylphosphine2×HCID 24290Palladium ChlorideHCID 66189TetravinylstannaneHCID 106845682-Chloro-6-(hydroxymethyl)-4-iodo-3-pyridinol

Product 1

HCID 223132782-Chloro-6-(hydroxymethyl)-4-vinylpyridin-3-ol

Sources & evidence

ORD record
ord-ed464d116605440c9822aaec78dc3790
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Linked notes

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