Piperazine → 1-[2-(2,6-Dimethyl-phenoxy)ethyl]piperazine

HRID 128205

Reaction equation

HRID 128205 reaction equation
[CH3:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]([CH3:12])[C:3]=1[O:4][CH2:5][CH2:6]Br.[I-].[Na+].C(=O)([O-])[O-].[K+].[K+].[NH:21]1[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1>CC(CC)=O>[CH3:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]([CH3:12])[C:3]=1[O:4][CH2:5][CH2:6][N:21]1[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1

Participants

6

Reactant 4

HCID 4837PiperazineHCID 5238Sodium IodideHCID 11430Potassium CarbonateHCID 24522082-(2-Bromoethoxy)-1,3-dimethylbenzene

Product 1

HCID 234686521-[2-(2,6-Dimethyl-phenoxy)ethyl]piperazine

Reagents, catalysts & solvents 1

HCID 6569Methyl Ethyl KetoneSolvent

Procedure

To methylethylketone (1 liter) are added 2-(2,6-dimethylphenoxy)-1-bromo-ethane (132 g), sodium iodide (85 g), potassium carbonate (80 g) and piperazine (200 g). The mixture is refluxed for 24 hours, with stirring. After cooling, the mixture is filtered and then washed with 3×300 ml benzene. After evaporation of the benzene, the piperazine derivative is distilled; b.p. 25 mm Hg=190° C.

Workup

  1. temperatureThe mixture is refluxed for 24 hours
  2. temperatureAfter cooling
  3. filtrationthe mixture is filtered
  4. washwashed with 3×300 ml benzene
  5. customAfter evaporation of the benzene
  6. distillationthe piperazine derivative is distilled
  7. customb.p. 25 mm Hg=190° C.

Sources & evidence

ORD record
ord-81ef5e212bdb488faab82b396a9fc6ad
Source dataset
uspto-grants-1981_03
Patent number
US04259334

Linked notes

Loading…