Water → Paclitaxel

HRID 131749

Reaction equation

HRID 131749 reaction equation
C(N(CC(O)=O)CCN(CC(O)=O)CC(O)=O)CN(CC(O)=O)CC(O)=O.[CH3:28][C:29]1[C@@H:46]([O:47][C:48]([C@H:50]([OH:67])[C@@H:51]([NH:58][C:59]([C:61]2[CH:62]=[CH:63][CH:64]=[CH:65][CH:66]=2)=[O:60])[C:52]2[CH:53]=[CH:54][CH:55]=[CH:56][CH:57]=2)=[O:49])[CH2:45][C@:41]2([OH:68])[C:42]([CH3:44])([CH3:43])[C:30]=1[C@@H:31]([O:86][C:87]([CH3:89])=[O:88])[C:32]([C@@:34]1([CH3:85])[C@H:39]([C@@H:40]2[O:69][C:70]([C:72]2[CH:73]=[CH:74][CH:75]=[CH:76][CH:77]=2)=[O:71])[C@:38]2([O:80][C:81]([CH3:83])=[O:82])[CH2:78][O:79][C@@H:37]2[CH2:36][C@@H:35]1[OH:84])=[O:33].C([O-])(O)=O.[Na+].O>C(O)C>[CH3:28][C:29]1[C@@H:46]([O:47][C:48]([C@H:50]([OH:67])[C@@H:51]([NH:58][C:59]([C:61]2[CH:66]=[CH:65][CH:64]=[CH:63][CH:62]=2)=[O:60])[C:52]2[CH:53]=[CH:54][CH:55]=[CH:56][CH:57]=2)=[O:49])[CH2:45][C@:41]2([OH:68])[C:42]([CH3:43])([CH3:44])[C:30]=1[C@@H:31]([O:86][C:87]([CH3:89])=[O:88])[C:32]([C@@:34]1([CH3:85])[C@H:39]([C@@H:40]2[O:69][C:70]([C:72]2[CH:77]=[CH:76][CH:75]=[CH:74][CH:73]=2)=[O:71])[C@:38]2([O:80][C:81]([CH3:83])=[O:82])[CH2:78][O:79][C@@H:37]2[CH2:36][C@@H:35]1[OH:84])=[O:33]

Participants

5

Reactant 3

HCID 962WaterHCID 516892Sodium BicarbonateHCID 86583879DTPA paclitaxel

Product 1

HCID 36314Paclitaxel

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The sodium salt of DTPA-paclitaxel was also obtained by adding a solution of DTPA-paclitaxel in ethanol into an equivalent amount of 0.05 M NaHCO3, followed by lyophilizing to yield a water-soluble solid powder (solubility>20 mg equivalent paclitaxel/ml).

Sources & evidence

ORD record
ord-68a1b04f08a14dc8b77820cd50f64b15
Source dataset
uspto-grants-2008_06
Patent number
US07384977B2

Linked notes

Loading…