Hydrochloric Acid → HCID 178493936, compound

HRID 1368778

Reaction equation

HRID 1368778 reaction equation
Cl.[NH2:2][C:3]([NH2:5])=[NH:4].[O-]CC.[Na+].[CH3:10][O:11][CH:12]([C:17](OC)=[O:18])[C:13](OC)=[O:14].Cl>C(O)C>[NH2:4][C:3]1[N:5]=[C:17]([OH:18])[C:12]([O:11][CH3:10])=[C:13]([OH:14])[N:2]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 5742Guanidine HydrochlorideHCID 78718Dimethyl methoxymalonateHCID 2723922Sodium ethoxide

Product 1

HCID 178493936HCID 178493936, compoundYield 20.6%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture composed of 12 g of guanidine hydrochloride, 9 g of sodium ethoxide and 100 ml of ethanol was heated under reflux for 1 hour, and then the reaction solution was cooled to room temperature, further mixed with 10 g of dimethyl methoxymalonate and heated under reflux for 48 hours. The reaction solution was cooled to room temperature, adjusted to a pH value of about 4 by adding 1 N hydrochloric acid solution and stirred, and then the thus precipitated powder was collected by filtration to obtain 2.0 g of the title compound.

Workup

  1. temperaturewas heated
  2. temperatureunder reflux for 1 hour
  3. temperatureheated
  4. temperatureunder reflux for 48 hours
  5. temperatureThe reaction solution was cooled to room temperature
  6. filtrationthe thus precipitated powder was collected by filtration

Sources & evidence

ORD record
ord-84d371195f7d4e7f89a35111ab491ef2
Source dataset
uspto-grants-2003_06
Patent number
US06573377B1

Linked notes

Loading…