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Hydrochloric Acid → HCID 54437783, compound

HRID 1374985
Notes
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Reaction equation

HRID 1374985 reaction equation
[CH2:1]([NH2:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(=O)([O-])[O-].[K+].[K+].[CH3:15][O:16][C:17](=[O:34])[C@H:18]([NH:29][C:30](=[O:33])[CH2:31]Cl)[CH2:19][C:20]1[CH:25]=[CH:24][C:23]([CH3:26])=[C:22]([O:27][CH3:28])[CH:21]=1.Cl>CN(C)C=O.ClCCl>[CH3:15][O:16][C:17](=[O:34])[C@H:18]([NH:29][C:30](=[O:33])[CH2:31][NH:8][CH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)[CH2:19][C:20]1[CH:25]=[CH:24][C:23]([CH3:26])=[C:22]([O:27][CH3:28])[CH:21]=1
ParticipantsConditionsProcedureWorkupSources & evidenceReaction notes

Participants

7

Reactant 4

HCID 313Hydrochloric AcidHCID 7504BenzylamineHCID 11430Potassium CarbonateHCID 54076724HCID 54076724, compound

Product 1

HCID 54437783HCID 54437783, compound

Reagents, catalysts & solvents 2

HCID 6228Dimethylformamide
Solvent
HCID 6344DichloromethaneSolvent

Conditions

Temperature
35 °C

Procedure

Benzylamine (1.65 g) and potassium carbonate (1.28 g) were added successively to a solution of (2R)-2-[N-(chloroacetyl)amino]-3-(3-methoxy-4-methylphenyl)propionic acid methyl ester (1.85 g) in N,N-dimethylformamide (15 ml) at 20° C. After being stirred at 35° C. for 1.5 hours, the mixture was poured into a mixture of ice-water (20 ml) and dichloromethane (20 ml). After the mixture was adjusted to pH 9 with diluted aqueous hydrochloric acid under stirring, the organic layer was separated, washed with brine (20 ml), dried over magnesium sulfate and evaporated under reduced pressure to give an oil of (2R)-2-[N-(benzylaminoacetyl)-amino]-3-(3-methoxy-4-methylphenyl)propionic acid methyl ester. A solution of (2R)-2-[N-(benzylaminoacetyl)amino]-3-(3-methoxy-4-methylphenyl)propionic acid methyl ester obtained by above procedure and acetic acid (0.18 ml) in isopropyl alcohol (10 ml) was stirred for 12 hours under reflux.

Workup

  1. stirringunder stirring
  2. customthe organic layer was separated
  3. washwashed with brine (20 ml)
  4. dry with materialdried over magnesium sulfate
  5. customevaporated under reduced pressure

Sources & evidence

ORD record
ord-2780cb9309fa430c996dc542320aff99
Source dataset
uspto-grants-2007_01
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US07166598B2

Reaction notes

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On this pageParticipantsConditionsProcedureWorkupSources & evidenceReaction notes