Chloride → 6-(2,6-Difluorophenyl)-quinoline

HRID 139748

Reaction equation

HRID 139748 reaction equation
[Br:14][c:15]1[cH:16][c:17]2[cH:18][cH:19][cH:20][n:21][c:22]2[cH:23][cH:24]1.[CH2:1]([Li:2])[CH2:3][CH2:4][CH3:5].[Cl-:30].[Cl-:32].[F:6][c:7]1[cH:8][cH:9][cH:10][c:11]([F:12])[cH:13]1.[O:25]1[CH2:26][CH2:27][CH2:28][CH2:29]1.[Zn+2:31]>>[F:6][c:7]1[cH:8][cH:9][cH:10][c:11]([F:12])[c:13]1-[c:15]1[cH:16][c:17]2[cH:18][cH:19][cH:20][n:21][c:22]2[cH:23][cH:24]1

Participants

7

Reactant 6

HCID 312Chloride2×HCID 8028TetrahydrofuranHCID 97411,3-DifluorobenzeneHCID 32051Zinc(2+)HCID 792436-BromoquinolineHCID 178418339Butyllithium

Product 1

HCID 137730476-(2,6-Difluorophenyl)-quinoline

Sources & evidence

ORD record
ord-7242791c0260488da3a3aea7734e24e9
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Linked notes

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