Sodium Hydroxide → 5-Hydrazinyl-2-methoxypyridine

Sodium nitrite (3.795 g) in water (20 mL) was added dropwise to 5-amino-2-methoxypyridine (6.207 g) in concentrated hydrochloric acid (50 mL) for 80 minutes with ice cooling, followed by stirring at a constant temperature for 30 minutes. Tin(II) chloride dihydrate (39.5 g) in concentrated hydrochloric acid (30 mL) was added dropwise to the reaction mixture at an internal temperature of about 10° C. for 60 minutes, followed by stirring at room temperature for 12.5 hours. Under cooling with ice, sodium hydroxide (54 g) in water (200 mL) and chloroform were added to the reaction mixture. After insoluble substances in the resultant mixture were removed by filtration, the mixture was partitioned. The aqueous layer was extracted with chloroform twice. The organic layers were combined, and dried over sodium sulfate anhydrate, followed by filtration. The solvent was evaporated under reduced pressure, to thereby give the title compound as crystals (4.23 g, 60%).

1. stirringby stirring at room temperature for 12.5 hours
2. additionwere added to the reaction mixture
3. customAfter insoluble substances in the resultant mixture were removed by filtration
4. customthe mixture was partitioned
5. extractionThe aqueous layer was extracted with chloroform twice
6. dry with materialdried over sodium sulfate anhydrate
7. filtrationfollowed by filtration
8. customThe solvent was evaporated under reduced pressure

ORD record

ord-e679c4bd3bf243499bfbcbe201c67bae

Source dataset

uspto-grants-2009_11

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07622471B2