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Sodium Bicarbonate → HCID 22106607, compound

HRID 1456312
Notes
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Reaction equation

HRID 1456312 reaction equation
O1CCOC1[N:6]1[N:10]=[C:9]([S:11]([CH3:14])(=[O:13])=[O:12])[N:8]([C:15]2[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[CH:17][CH:16]=2)[NH:7]1.[C:23](=O)(O)[O-:24].[Na+]>O1CCCC1.Cl.[Cl-].[Na+].O>[CH3:14][S:11]([C:9]1[N:8]([C:15]2[CH:16]=[CH:17][C:18]([O:21][CH3:22])=[C:19]([CH:20]=2)[CH:23]=[O:24])[N:7]=[N:6][N:10]=1)(=[O:12])=[O:13]
ParticipantsProcedureWorkupSources & evidenceReaction notes

Participants

6

Reactant 2

HCID 516892Sodium BicarbonateHCID 867533893-[1,3]Dioxolan-2-yl(4-methoxy-phenyl)-5-methanesulfonyl-1H-tetrazole

Product 1

HCID 22106607HCID 22106607, compound

Reagents, catalysts & solvents 3

HCID 313Hydrochloric AcidSolventHCID 8028TetrahydrofuranSolvent
HCID 57417360
Sodium chloride; water
Solvent

Procedure

1-(3-[1,3]Dioxolan-2-yl(4-methoxy-phenyl)-5-methanesulfonyl-1H-tetrazole (800 mg) in tetrahydrofuran (13 ml) and hydrochloric acid (2N, 7.5 ml) was stirred at room temperature for 1.5 h. The solution was basified with sodium bicarbonate solution (8%), saturated with brine (50 ml), extracted with ether (3×50 ml), dried (Na2SO4) and evaporated to give the title compound as an orange solid (307 mg).

Workup

  1. extractionextracted with ether (3×50 ml)
  2. dry with materialdried (Na2SO4)
  3. customevaporated

Sources & evidence

ORD record
ord-5f0af16ecc464ebd851668131fc7ff89
Source dataset
uspto-grants-1998_12
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US05843966

Reaction notes

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On this pageParticipantsProcedureWorkupSources & evidenceReaction notes