Ammonium → N-t-butyl-3-(fluoroacetyl)-2-thiophenesulfonamide

HRID 145976

Reaction equation

HRID 145976 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[NH:5][S:6](=[O:7])(=[O:8])[c:9]1[s:10][cH:11][cH:12][c:13]1[Br:14].[CH2:15]([Li:16])[CH2:17][CH2:18][CH3:19].[CH2:34]([O:35][C:36](=[O:37])[CH3:38])[CH3:39].[Cl-:27].[F:20][CH2:21][C:22](=[O:23])[O:24][CH2:25][CH3:26].[NH4+:28].[O:29]1[CH2:30][CH2:31][CH2:32][CH2:33]1>>[C:1]([CH3:2])([CH3:3])([CH3:4])[NH:5][S:6](=[O:7])(=[O:8])[c:9]1[s:10][cH:11][cH:12][c:13]1[C:22]([CH2:21][F:20])=[O:23]

Participants

8

Reactant 7

HCID 223AmmoniumHCID 312ChlorideHCID 8028TetrahydrofuranHCID 8857Ethyl AcetateHCID 9988Ethyl fluoroacetateHCID 140519253-bromo-N-tert-butylthiophene-2-sulfonamideHCID 178418339Butyllithium

Product 1

HCID 19690781N-t-butyl-3-(fluoroacetyl)-2-thiophenesulfonamide

Sources & evidence

ORD record
ord-16ad7775dcba4631a71d215a8b922bf6
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Linked notes

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