Water → 2-[4-(Aminomethyl)piperidin-1-yl]ethan-1-ol
Reaction equation
[OH:1][CH2:2][CH2:3][N:4]1[CH2:9][CH2:8][CH:7]([C:10]#[N:11])[CH2:6][CH2:5]1.S(C)C.O.C([O-])([O-])=O.[K+].[K+]>C1COCC1>[NH2:11][CH2:10][CH:7]1[CH2:6][CH2:5][N:4]([CH2:3][CH2:2][OH:1])[CH2:9][CH2:8]1Participants
6
Conditions
- Temperature
- 0 °C
Procedure
To the solution of compound 1-(2-hydroxyethyl)piperidine-4-carbonitrile (300 mg, 2 mmol) in dry THF (5 mL) at 0° C., BH3.SMe2 (220 mg, 2.4 mmol) was added dropwise. The mixture was stirred at 0° C. for 2 hrs. Water was added then K2CO3. The mixture was filtered and concentrated to give compound 2-(4-(aminomethyl)piperidin-1-yl)ethanol (150 mg, 47%).
Workup
- customat 0° C.
- filtrationThe mixture was filtered
- concentrationconcentrated
Sources & evidence
- ORD record
- ord-6305663d1f8f42548e4053b3e2985a2f
- Source dataset
- uspto-grants-2016_08
- Patent number
- US09416132B2
Reaction notes
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