Benzaldehyde → Diethyl aminobenzaldehyde

HRID 1492683

Reaction equation

HRID 1492683 reaction equation
[C@@H]1([N:9]2[CH:17]=[C:15]([CH3:16])[C:13](=[O:14])NC2=O)O[C@H](CO)[C@@H](O)C1.C1N(CCO)CCN(CCS(O)(=O)=O)C1.C1N=C(N)C2N=CN([C@@H]3O[C@H](COP(OP(OC[C@H]4O[C@@H](N5C=C(C(N)=O)CC=C5)[C@H](O)[C@@H]4O)(O)=O)(O)=O)[C@@H](O)[C@H]3O)C=2N=1.C1C=[N+]([C@@H]2O[C@H](COP(OP(OC[C@H]3O[C@@H](N4C5N=CN=C(N)C=5N=C4)[C@H](OP(O)(O)=O)[C@@H]3O)(O)=O)(O)=O)[C@@H](O)[C@H]2O)C=C(C(N)=O)C=1.C(C=C)=O.CCN(C(SSC(N(CC)CC)=S)=S)CC.C(=O)CC.[CH:149](=O)[C:150]1[CH:155]=[CH:154][CH:153]=[CH:152][CH:151]=1>>[CH2:155]([C:150]1[CH:149]=[CH:16][C:15]([CH:13]=[O:14])=[C:17]([NH2:9])[C:151]=1[CH2:152][CH3:153])[CH3:154]

Participants

9

Reactant 8

HCID 240BenzaldehydeHCID 527PropanalHCID 3117DisulfiramHCID 5789ThymidineHCID 5886NADP nicotinamide-adenine-dinucleotide phosphateHCID 7847AcroleinHCID 238314-(2-Hydroxyethyl)-1-piperazineethanesulfonic acidHCID 439153Nadh

Product 1

HCID 54482978Diethyl aminobenzaldehyde

Procedure

Materials: SDA was prepared by acid hydrolysis of the corresponding bioacetal supplied by the Department of Pharmaceutical Development at our Institute. [3H]-Thymidine was purchased from New England Nuclear, Boston, Mass. Concanavalin A, horse serum, RPMI-1640 and HEPES were from Gibco, Grand Island, N.Y. NAD and NADP were purchased from Boehringer, Mannheim. Acrolein and disulfiram were obtained from Aldrich Chemical Co., Milwaukee, Wis. Propionaldehyde and benzaldehyde were from Eastman Kodak Chemical Co., Rochester, N.Y. Diethyl aminobenzaldehyde (DEAB) was kindly provided by Dr. John Hilton, Johns Hopkins School of Medicine, Baltimore, Md.

Workup

  1. customMaterials: SDA was prepared by acid hydrolysis of the corresponding bioacetal

Sources & evidence

ORD record
ord-5424f1799aac4456a064308777a3601d
Source dataset
uspto-grants-1994_12
Patent number
US05374658

Linked notes

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