Reaction equation
C(N(CC)CC)C.[CH3:8][O:9][CH2:10]Cl.O1CCCC1.[F:17][C:18]1[CH:26]=[CH:25][C:21]([C:22]([OH:24])=O)=[CH:20][C:19]=1[OH:27]>C(OCC)(=O)C>[F:17][C:18]1[CH:26]=[CH:25][C:21]([CH2:22][OH:24])=[CH:20][C:19]=1[O:27][CH2:8][O:9][CH3:10]Participants
Conditions
- Temperature
- 0 °C
Procedure
Triethylamine (1.07 mL) and methoxymethyl chloride (2.24 mL) were added to tetrahydrofuran (10 mL) solution of 4-fluoro-3-hydroxybenzoic acid (1.0 g), and stirred at 0° C. for 2 hours. Ethyl acetate was added to the reaction liquid which then was washed with water and saturated brine, dried over anhydrous magnesium sulfate, the solvent therein was concentrated under reduced pressure and the residue was dissolved in tetrahydrofuran (20 mL). Lithiumaluminium hydride (360 mg) was added, stirred at 0° C. for an hour, ethyl acetate was added and the insoluble matter was removed, followed by washing with saturated brine and drying over anhydrous magnesium sulfate. Concentrating the solvent under reduced pressure, the title compound (1.14 g, 94%) was obtained.
Workup
- washthen was washed with water and saturated brine
- dry with materialdried over anhydrous magnesium sulfate
- concentrationthe solvent therein was concentrated under reduced pressure
- dissolutionthe residue was dissolved in tetrahydrofuran (20 mL)
- additionLithiumaluminium hydride (360 mg) was added
- stirringstirred at 0° C. for an hour
- additionethyl acetate was added
- customthe insoluble matter was removed
- washby washing with saturated brine
- dry with materialdrying over anhydrous magnesium sulfate
- concentrationConcentrating the solvent under reduced pressure
Sources & evidence
- ORD record
- ord-b32e232e6caf496cb7414acd838cedd1
- Source dataset
- uspto-grants-2010_06
- Patent number
- US07732456B2
Linked notes
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