4-Methylmorpholine → (2-Bromo-4-nitrophenyl)(pyrrolidin-1-yl)methanone
Reaction equation
[Br:1][C:2]1[CH:10]=[C:9]([N+:11]([O-:13])=[O:12])[CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=O.[NH:14]1[CH2:18][CH2:17][CH2:16][CH2:15]1.CN(C(ON1N=NC2C=CC=CC1=2)=[N+](C)C)C.[B-](F)(F)(F)F.CN1CCOCC1>CN(C=O)C>[Br:1][C:2]1[CH:10]=[C:9]([N+:11]([O-:13])=[O:12])[CH:8]=[CH:7][C:3]=1[C:4]([N:14]1[CH2:18][CH2:17][CH2:16][CH2:15]1)=[O:6]Participants
6
Reactant 4
Product 1
Reagents, catalysts & solvents 1
Procedure
Prepared analogously to Example 1a from 2-bromo-4-nitro-benzoic acid and pyrrolidine with TBTU and NMM in DMF.
Sources & evidence
- ORD record
- ord-1048e2e281ec483fb3412695eaac9f3d
- Source dataset
- uspto-grants-2010_06
- Patent number
- US07732466B2
Reaction notes
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