Dimethylformamide → (4-Chlorocarbonyl-6-fluoro-3-methyl-naphthalen-2-yl)-acetic acid methyl ester

Reaction equation

[CH3:27][N:28]([CH3:29])[CH:30]=[O:31].[Cl:21][C:22]([C:23]([Cl:24])=[O:25])=[O:26].[F:1][c:2]1[cH:3][cH:4][c:5]2[cH:6][c:7]([CH2:16][C:17](=[O:18])[O:19][CH3:20])[c:8]([CH3:15])[c:9]([C:12](=[O:13])[OH:14])[c:10]2[cH:11]1.[O:32]1[CH2:33][CH2:34][CH2:35][CH2:36]1>>[F:1][c:2]1[cH:3][cH:4][c:5]2[cH:6][c:7]([CH2:16][C:17](=[O:18])[O:19][CH3:20])[c:8]([CH3:15])[c:9]([C:12](=[O:13])[Cl:21])[c:10]2[cH:11]1

Participants

Reactant 4

HCID 6228Dimethylformamide

HCID 8028Tetrahydrofuran

HCID 65578Oxalyl chloride

HCID 593267347-Fluoro-3-methoxycarbonylmethyl-2-methyl-naphthalene-1-carboxylic acid

Product 1

HCID 59326710(4-Chlorocarbonyl-6-fluoro-3-methyl-naphthalen-2-yl)-acetic acid methyl ester

Sources & evidence

ORD record: ord-0a76e2c81b0c482ea30fbc10e041641b
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (1/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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