Cyclohexyl bromide → {5-[(Cyclohexyl)-(4-fluoro-benzenesulfonyl)-amino]-2-propyl-benzoimidazol-1-yl}-acetic acid tert-butyl ester

HRID 15552

Reaction equation

[CH:1]1(Br)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.C([O-])([O-])=O.[K+].[K+].[C:14]([O:18][C:19](=[O:44])[CH2:20][N:21]1[C:25]2[CH:26]=[CH:27][C:28]([NH:30][S:31]([C:34]3[CH:39]=[CH:38][C:37]([F:40])=[CH:36][CH:35]=3)(=[O:33])=[O:32])=[CH:29][C:24]=2[N:23]=[C:22]1[CH2:41][CH2:42][CH3:43])([CH3:17])([CH3:16])[CH3:15]>CC#N.CCOC(C)=O.O>[C:14]([O:18][C:19](=[O:44])[CH2:20][N:21]1[C:25]2[CH:26]=[CH:27][C:28]([N:30]([CH:1]3[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]3)[S:31]([C:34]3[CH:35]=[CH:36][C:37]([F:40])=[CH:38][CH:39]=3)(=[O:32])=[O:33])=[CH:29][C:24]=2[N:23]=[C:22]1[CH2:41][CH2:42][CH3:43])([CH3:17])([CH3:16])[CH3:15]

Participants

Conditions

Temperature: 80 °C

Procedure

Cyclohexyl bromide (0.27 mmol) and K2CO3 (63 mg, 0.45 mmol) were added to a solution of [5-(4-fluoro-benzenesulfonylamino)-2-propyl-benzoimidazol-1-yl]-acetic acid tert-butyl ester (40 mg, 0.09 mmol) in CH3CN (1 mL), and stirred overnight at 80° C. The reaction mixture was diluted with EtOAc and H2O, and then filtered through an Extrelut column. The column was washed with EtOAc, and the filtrate was concentrated. The crude product was carried onto the next reaction without any further purification or characterization.

Workup

filtrationfiltered through an Extrelut column
washThe column was washed with EtOAc
concentrationthe filtrate was concentrated
customThe crude product was carried onto the next reaction without any further purification or characterization

Sources & evidence

ORD record: ord-b83b3ed8d3fb450bb72195da87993890
Source dataset: uspto-grants-2010_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07732618B2

Linked notes

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