Piperidine → 4-Chloro-1-(piperidin-1-yl)butan-1-one
Reaction equation
[Cl:1][CH2:2][CH2:3][CH2:4][C:5](Cl)=[O:6].[NH:8]1[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]1.C(N(CC)CC)C>ClCCl>[Cl:1][CH2:2][CH2:3][CH2:4][C:5]([N:8]1[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]1)=[O:6]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
4-Chlorobutyryl chloride in dichlormethane was added to an ice cooled solution of piperidine (1.8 ml; 17.6 mmol) and triethylamine (2.5 ml) in dichloromethane (40 ml) under an atmosphere of nitrogen. The mixture was stirred for 5 min whilst being cooled, then stirred at ambient temperature for 3 h. The solution was washed with water, dried over sodium sulfate and evaporated to give 1-(4-chloro-1-oxobutyl)piperidine as a pale yellow oil (2.1 g).
Workup
- temperaturewhilst being cooled
- stirringstirred at ambient temperature for 3 h
- washThe solution was washed with water
- dry with materialdried over sodium sulfate
- customevaporated
Sources & evidence
- ORD record
- ord-891d443741d64ed497ff037d8fccf181
- Source dataset
- uspto-grants-1999_08
- Patent number
- US05935974
Reaction notes
Loading…