Hydrochloric Acid → 4-Fluoro-N-[3-(1H-imidazol-1-yl)propyl]benzeneacetamide

Reaction equation

[C:12]([n:13]1[cH:14][cH:15][n:16][cH:17]1)([n:18]1[cH:19][cH:20][n:21][cH:22]1)=[O:23].[ClH:29].[ClH:30].[F:1][c:2]1[cH:3][cH:4][c:5]([CH2:8][C:9](=[O:10])[OH:11])[cH:6][cH:7]1.[O:24]1[CH2:25][CH2:26][CH2:27][CH2:28]1.[OH2:40].[n:31]1([CH2:36][CH2:37][CH2:38][NH2:39])[cH:32][n:33][cH:34][cH:35]1>>[F:1][c:2]1[cH:3][cH:4][c:5]([CH2:8][C:9](=[O:11])[NH:39][CH2:38][CH2:37][CH2:36][n:31]2[cH:32][n:33][cH:34][cH:35]2)[cH:6][cH:7]1

Participants

Reactant 6

HCID 313Hydrochloric Acid2×

HCID 962Water

HCID 8028Tetrahydrofuran

HCID 98372-(4-Fluorophenyl)acetic acid

HCID 682631,1'-Carbonyldiimidazole

HCID 787361H-Imidazole-1-propanamine

Product 1

HCID 135889554-Fluoro-N-[3-(1H-imidazol-1-yl)propyl]benzeneacetamide

Sources & evidence

ORD record: ord-310be4d9bd944e1d82c604ced932ace2
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (9/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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