Tetrahydrofuran → Tert-butyl 4-cyano-4-(cyclopropylmethyl)piperidine-1-carboxylate

HRID 163243

Reaction equation

HRID 163243 reaction equation
[Br:24][CH2:25][CH:26]1[CH2:27][CH2:28]1.[C:9](#[N:10])[CH:11]1[CH2:12][CH2:13][N:14]([C:17](=[O:18])[O:19][C:20]([CH3:21])([CH3:22])[CH3:23])[CH2:15][CH2:16]1.[CH2:29]1[O:30][CH2:31][CH2:32][CH2:33]1.[CH:1]([N-:2][CH:3]([CH3:4])[CH3:5])([CH3:6])[CH3:7].[Li+:8]>>[C:9](#[N:10])[C:11]1([CH2:25][CH:26]2[CH2:27][CH2:28]2)[CH2:12][CH2:13][N:14]([C:17](=[O:18])[O:19][C:20]([CH3:21])([CH3:22])[CH3:23])[CH2:15][CH2:16]1

Participants

6

Reactant 5

HCID 8028TetrahydrofuranHCID 28486Lithium ionHCID 81503BromomethylcyclopropaneHCID 1514443Tert-butyl 4-cyanopiperidine-1-carboxylateHCID 5062348Diisopropylamide

Product 1

HCID 57425738Tert-butyl 4-cyano-4-(cyclopropylmethyl)piperidine-1-carboxylate

Sources & evidence

ORD record
ord-34e175039db24f238be669c1a73610a3
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Linked notes

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