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Tris(1,1-dimethylethyl)phosphine → 1-(Tetrahydro-2H-pyran-4-yl)-1H-indol-5-amine

HRID 1668481
Notes
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Reaction equation

HRID 1668481 reaction equation
Br[C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([CH:11]1[CH2:16][CH2:15][O:14][CH2:13][CH2:12]1)[CH:6]=[CH:5]2.C(P(C(C)(C)C)C(C)(C)C)(C)(C)C.C[Si]([N-:34][Si](C)(C)C)(C)C.[Li+]>C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.[Pd].[Pd].O1CCCC1>[O:14]1[CH2:15][CH2:16][CH:11]([N:7]2[C:8]3[C:4](=[CH:3][C:2]([NH2:34])=[CH:10][CH:9]=3)[CH:5]=[CH:6]2)[CH2:12][CH2:13]1
ParticipantsProcedureWorkupSources & evidenceReaction notes

Participants

6

Reactant 3

HCID 83681Tris(1,1-dimethylethyl)phosphineHCID 2733832Lithium hexamethyldisilazaneHCID 590046455-Bromo-1-(tetrahydro-2H-pyran-4-yl)-1H-indole

Product 1

HCID 590046181-(Tetrahydro-2H-pyran-4-yl)-1H-indol-5-amineYield 88.8%

Reagents, catalysts & solvents 2

HCID 9811564
Bis(dibenzylideneacetone)palladium
Catalyst
HCID 8028TetrahydrofuranSolvent2×

Procedure

Compound 88 (140 mg, 0.500 mmol), tris(dibenzylideneacetone)dipalladium (0) (45.7 mg, 0.050 mmol) and anhydrous tetrahydrofuran (15 mL) were charged to a dry argon purged flask fitted with magnetic stir bar and condenser. A solution of tri-tert-butylphosphine (10 wt % in hexane, 202.3 mg, 0.100 mmol) is added followed by dropwise addition of a 1M tetrahydrofuran solution of lithium bis(trimethylsilyl)amide (1.500 ml, 1.500 mmol) and mixture refluxed for a period of 45 minutes. The mixture was cooled to room temperature then to 0° C., quenched with 1M HCl (10 mL) and stirred for 15 minutes. The solution was diluted with ethyl acetate and conc. NH4OH added to adjust pH to 9. The mixture was transferred to a separatory funnel and the organic layer collected. The aqueous layer was further extracted with ethyl acetate and the combined organic layers were washed with brine, dried over magnesium sulphate, filtered, concentrated and the residue purified via chromatography on silica gel (EtOAc: Hexanes, 7:3) to yield a pale brown solid 89 (96 mg, 88.8%). 1H NMR (DMSO-d6) δ 1.80-1.99 (m, 4H), 3.53 (dt, 2H, J=11.4, 2.9 Hz), 3.95-3.99 (m, 2H), 4.39-4.50 (m, 1H), 4.55 (brs, 2H), 6.14 (d, 1H, J=4.1 Hz), 6.52 (dd, 1H, J=8.8, 2.1 Hz), 6.68 (d, 1H, J=1.9 Hz), 7.23 (d, 1H, J=8.6 Hz), 7.27 (d, 1H, J=3.2 Hz); ESI-MS (m/z, %): 217 (MH+, 100%).

Workup

  1. customfitted with magnetic stir bar and condenser
  2. temperaturerefluxed for a period of 45 minutes
  3. customto 0° C., quenched with 1M HCl (10 mL)
  4. additionThe solution was diluted with ethyl acetate and conc. NH4OH
  5. additionadded
  6. customThe mixture was transferred to a separatory funnel
  7. customthe organic layer collected
  8. extractionThe aqueous layer was further extracted with ethyl acetate
  9. washthe combined organic layers were washed with brine
  10. dry with materialdried over magnesium sulphate
  11. filtrationfiltered
  12. concentrationconcentrated
  13. customthe residue purified via chromatography on silica gel (EtOAc: Hexanes, 7:3)

Sources & evidence

ORD record
ord-5926c278447a4027886654218b123775
Source dataset
uspto-grants-2011_08
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US07989447B2

Reaction notes

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