Water → (R)-3-[4-(3-Amino-benzo[d]isoxazol-6-yl)-2,6-dichloro-benzyl]-1-(4-hydroxy-piperidin-1-yl)-pyrrolidin-2-one

Reaction equation

O.C(O)(C(F)(F)F)=O.[NH2:9][C:10]1[C:14]2[CH:15]=[CH:16][C:17]([C:19]3[CH:48]=[C:47]([Cl:49])[C:22]([CH2:23][C@@H:24]4[CH2:28][CH2:27][N:26]([N:29]5[CH2:34][CH2:33][CH:32]([O:35][Si](C(C)C)(C(C)C)C(C)C)[CH2:31][CH2:30]5)[C:25]4=[O:46])=[C:21]([Cl:50])[CH:20]=3)=[CH:18][C:13]=2[O:12][N:11]=1.C(OCC)(=O)C>C1COCC1>[NH2:9][C:10]1[C:14]2[CH:15]=[CH:16][C:17]([C:19]3[CH:48]=[C:47]([Cl:49])[C:22]([CH2:23][C@@H:24]4[CH2:28][CH2:27][N:26]([N:29]5[CH2:34][CH2:33][CH:32]([OH:35])[CH2:31][CH2:30]5)[C:25]4=[O:46])=[C:21]([Cl:50])[CH:20]=3)=[CH:18][C:13]=2[O:12][N:11]=1